| Reaction Details |
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 | Report a problem with these data |
| Target | 11-beta-hydroxysteroid dehydrogenase type 2 |
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| Ligand | BDBM50224216 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_450658 (CHEMBL900941) |
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| IC50 | 4500±n/a nM |
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| Citation |  Yuan, C; St Jean, DJ; Liu, Q; Cai, L; Li, A; Han, N; Moniz, G; Askew, B; Hungate, RW; Johansson, L; Tedenborg, L; Pyring, D; Williams, M; Hale, C; Chen, M; Cupples, R; Zhang, J; Jordan, S; Bartberger, MD; Sun, Y; Emery, M; Wang, M; Fotsch, C The discovery of 2-anilinothiazolones as 11beta-HSD1 inhibitors. Bioorg Med Chem Lett17:6056-61 (2007) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| 11-beta-hydroxysteroid dehydrogenase type 2 |
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| Name: | 11-beta-hydroxysteroid dehydrogenase type 2 |
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| Synonyms: | 11-DH2 | 11-beta-HSD2 | 11-beta-Hydroxysteroid Dehydrogenase 2 (11-beta-HSD2) | 11-beta-hydroxysteroid dehydrogenase | 11-beta-hydroxysteroid dehydrogenase 2 | 11-beta-hydroxysteroid dehydrogenase type 2 | 11-beta-hydroxysteroid dehydrogenase type 2 (11-beta-HSD2) | Corticosteroid 11-beta-dehydrogenase isozyme 2 | DHI2_HUMAN | HSD11B2 | HSD11K | NAD-dependent 11-beta-hydroxysteroid dehydrogenase | SDR9C3 |
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| Type: | Enzyme |
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| Mol. Mass.: | 44141.72 |
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| Organism: | Homo sapiens (Human) |
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| Description: | Purified recombinant human 11beta-HSD2. |
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| Residue: | 405 |
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| Sequence: | MERWPWPSGGAWLLVAARALLQLLRSDLRLGRPLLAALALLAALDWLCQRLLPPPAALAV
LAAAGWIALSRLARPQRLPVATRAVLITGCDSGFGKETAKKLDSMGFTVLATVLELNSPG
AIELRTCCSPRLRLLQMDLTKPGDISRVLEFTKAHTTSTGLWGLVNNAGHNEVVADAELS
PVATFRSCMEVNFFGALELTKGLLPLLRSSRGRIVTVGSPAGDMPYPCLGAYGTSKAAVA
LLMDTFSCELLPWGVKVSIIQPGCFKTESVRNVGQWEKRKQLLLANLPQELLQAYGKDYI
EHLHGQFLHSLRLAMSDLTPVVDAITDALLAARPRRRYYPGQGLGLMYFIHYYLPEGLRR
RFLQAFFISHCLPRALQPGQPGTTPPQDAAQDPNLSPGPSPAVAR
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| BDBM50224216 |
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| n/a |
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| Name | BDBM50224216 |
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| Synonyms: | 2-(2-chlorophenylamino)-5-cyclopentylthiazol-4(5H)-one | CHEMBL240052 |
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| Type | Small organic molecule |
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| Emp. Form. | C14H15ClN2OS |
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| Mol. Mass. | 294.8 |
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| SMILES | Oc1nc(Nc2ccccc2Cl)sc1C1CCCC1 |
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| Structure | 
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