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Target11-beta-hydroxysteroid dehydrogenase 1
LigandBDBM50224222
Substrate/Competitorn/a
Meas. Tech.ChEMBL_450656 (CHEMBL900939)
Ki 18±n/a nM
Citation Yuan, CSt Jean, DJLiu, QCai, LLi, AHan, NMoniz, GAskew, BHungate, RWJohansson, LTedenborg, LPyring, DWilliams, MHale, CChen, MCupples, RZhang, JJordan, SBartberger, MDSun, YEmery, MWang, MFotsch, C The discovery of 2-anilinothiazolones as 11beta-HSD1 inhibitors. Bioorg Med Chem Lett17:6056-61 (2007) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
11-beta-hydroxysteroid dehydrogenase 1
Name:11-beta-hydroxysteroid dehydrogenase 1
Synonyms:11-DH | 11-beta-HSD1 | 11-beta-Hydroxysteroid Dehydrogenase 1 (11-beta-HSD1) | 11-beta-hydroxysteroid dehydrogenase | 11-beta-hydroxysteroid dehydrogenase 1 (11HSD1) | Corticosteroid 11-beta-dehydrogenase isozyme 1 | Corticosteroid 11-beta-dehydrogenase isozyme 1 (11-beta-HSD-1) | Corticosteroid 11-beta-dehydrogenase isozyme 1 (11-beta-HSD1) | Corticosteroid 11-beta-dehydrogenase isozyme 1 (11beta-HSD1) | DHI1_HUMAN | HSD11 | HSD11B1 | HSD11L | SDR26C1
Type:Enzyme
Mol. Mass.:32409.16
Organism:Homo sapiens (Human)
Description:P28845
Residue:292
Sequence:
MAFMKKYLLPILGLFMAYYYYSANEEFRPEMLQGKKVIVTGASKGIGREMAYHLAKMGAH
VVVTARSKETLQKVVSHCLELGAASAHYIAGTMEDMTFAEQFVAQAGKLMGGLDMLILNH
ITNTSLNLFHDDIHHVRKSMEVNFLSYVVLTVAALPMLKQSNGSIVVVSSLAGKVAYPMV
AAYSASKFALDGFFSSIRKEYSVSRVNVSITLCVLGLIDTETAMKAVSGIVHMQAAPKEE
CALEIIKGGALRQEEVYYDSSLWTTLLIRNPCRKILEFLYSTSYNMDRFINK
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM50224222
n/a
NameBDBM50224222
Synonyms:2-(2,4-dichlorophenylamino)-5-isopropylthiazol-4(5H)-one | CHEMBL238312
TypeSmall organic molecule
Emp. Form.C12H12Cl2N2OS
Mol. Mass.303.207
SMILESCC(C)c1sc(Nc2ccc(Cl)cc2Cl)nc1O
Structure
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