Reaction Details |
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Target | C-C chemokine receptor type 2 |
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Ligand | BDBM50224501 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_450803 (CHEMBL899888) |
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IC50 | 2.5±n/a nM |
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Citation | Xia, M; Hou, C; DeMong, DE; Pollack, SR; Pan, M; Brackley, JA; Jain, N; Gerchak, C; Singer, M; Malaviya, R; Matheis, M; Olini, G; Cavender, D; Wachter, M Synthesis, structure-activity relationship and in vivo antiinflammatory efficacy of substituted dipiperidines as CCR2 antagonists. J Med Chem50:5561-3 (2007) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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C-C chemokine receptor type 2 |
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Name: | C-C chemokine receptor type 2 |
Synonyms: | C-C chemokine receptor type 2 (CCR2) | CCR2 | CCR2_HUMAN | CMKBR2 | Chemoattractant Cytokine Receptor 2 (CCR2) | Chemokine Receptor Type 2b (CCR2b) | Monocyte chemotactic protein-1 (MCP-1) |
Type: | Enzyme |
Mol. Mass.: | 41932.32 |
Organism: | Homo sapiens (Human) |
Description: | P41597 |
Residue: | 374 |
Sequence: | MLSTSRSRFIRNTNESGEEVTTFFDYDYGAPCHKFDVKQIGAQLLPPLYSLVFIFGFVGN
MLVVLILINCKKLKCLTDIYLLNLAISDLLFLITLPLWAHSAANEWVFGNAMCKLFTGLY
HIGYFGGIFFIILLTIDRYLAIVHAVFALKARTVTFGVVTSVITWLVAVFASVPGIIFTK
CQKEDSVYVCGPYFPRGWNNFHTIMRNILGLVLPLLIMVICYSGILKTLLRCRNEKKRHR
AVRVIFTIMIVYFLFWTPYNIVILLNTFQEFFGLSNCESTSQLDQATQVTETLGMTHCCI
NPIIYAFVGEKFRSLFHIALGCRIAPLQKPVCGGPGVRPGKNVKVTTQGLLDGRGKGKSI
GRAPEASLQDKEGA
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BDBM50224501 |
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n/a |
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Name | BDBM50224501 |
Synonyms: | (E)-2-(4-(7-methoxy-1H-indol-3-yl)piperidin-1-yl)-2-(1-(3-(3,4,5-trifluorophenyl)acryloyl)piperidin-4-yl)acetic acid | CHEMBL392748 |
Type | Small organic molecule |
Emp. Form. | C30H32F3N3O4 |
Mol. Mass. | 555.588 |
SMILES | COc1cccc2c(c[nH]c12)C1CCN(CC1)C(C1CCN(CC1)C(=O)\C=C\c1cc(F)c(F)c(F)c1)C(O)=O |w:17.41| |
Structure |
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