| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Coagulation factor X |
|---|
| Ligand | BDBM50224694 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_458333 (CHEMBL941667) |
|---|
| Ki | 19±n/a nM |
|---|
| Citation |  Varnes, JG; Wacker, DA; Jacobson, IC; Quan, ML; Ellis, CD; Rossi, KA; He, MY; Luettgen, JM; Knabb, RM; Bai, S; He, K; Lam, PY; Wexler, RR Design, structure-activity relationship, and pharmacokinetic profile of pyrazole-based indoline factor Xa inhibitors. Bioorg Med Chem Lett17:6481-8 (2007) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Coagulation factor X |
|---|
| Name: | Coagulation factor X |
|---|
| Synonyms: | Activated coagulation factor X (FXa) | Activated factor Xa heavy chain | Coagulation factor X precursor | Coagulation factor Xa | F10 | FA10_HUMAN | Factor X heavy chain | Factor X light chain | Factor Xa | Stuart factor | Stuart-Prower factor |
|---|
| Type: | Enzyme |
|---|
| Mol. Mass.: | 54726.60 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | n/a |
|---|
| Residue: | 488 |
|---|
| Sequence: | MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEE
TCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKN
CELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERR
KRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQE
CKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGE
AVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGI
VSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSG
GPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPE
VITSSPLK
|
|
|
|---|
| BDBM50224694 |
|---|
| n/a |
|---|
| Name | BDBM50224694 |
|---|
| Synonyms: | (1-(3-aminobenzo[d]isoxazol-5-yl)-3-(trifluoromethyl)-1H-pyrazol-5-yl)(5-(2-((dimethylamino)methyl)phenyl)indolin-1-yl)methanone | CHEMBL248725 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C29H25F3N6O2 |
|---|
| Mol. Mass. | 546.543 |
|---|
| SMILES | CN(C)Cc1ccccc1-c1ccc2N(CCc2c1)C(=O)c1cc(nn1-c1ccc2onc(N)c2c1)C(F)(F)F |
|---|
| Structure | 
|
|---|
Search and Browse
