| Reaction Details |
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 | Report a problem with these data |
| Target | Coagulation factor X |
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| Ligand | BDBM50224704 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_458333 (CHEMBL941667) |
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| Ki | 0.63±n/a nM |
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| Citation |  Varnes, JG; Wacker, DA; Jacobson, IC; Quan, ML; Ellis, CD; Rossi, KA; He, MY; Luettgen, JM; Knabb, RM; Bai, S; He, K; Lam, PY; Wexler, RR Design, structure-activity relationship, and pharmacokinetic profile of pyrazole-based indoline factor Xa inhibitors. Bioorg Med Chem Lett17:6481-8 (2007) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Coagulation factor X |
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| Name: | Coagulation factor X |
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| Synonyms: | Activated coagulation factor X (FXa) | Activated factor Xa heavy chain | Coagulation factor X precursor | Coagulation factor Xa | F10 | FA10_HUMAN | Factor X heavy chain | Factor X light chain | Factor Xa | Stuart factor | Stuart-Prower factor |
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| Type: | Enzyme |
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| Mol. Mass.: | 54726.60 |
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| Organism: | Homo sapiens (Human) |
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| Description: | n/a |
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| Residue: | 488 |
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| Sequence: | MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEE
TCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKN
CELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERR
KRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQE
CKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGE
AVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGI
VSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSG
GPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPE
VITSSPLK
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| BDBM50224704 |
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| n/a |
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| Name | BDBM50224704 |
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| Synonyms: | 1-(3-aminobenzo[d]isoxazol-5-yl)-5-(5-(2-(pyrrolidin-1-ylmethyl)phenyl)indoline-1-carbonyl)-1H-pyrazole-3-carboxamide | CHEMBL399332 |
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| Type | Small organic molecule |
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| Emp. Form. | C31H29N7O3 |
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| Mol. Mass. | 547.6071 |
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| SMILES | NC(=O)c1cc(C(=O)N2CCc3cc(ccc23)-c2ccccc2CN2CCCC2)n(n1)-c1ccc2onc(N)c2c1 |
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| Structure | 
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