Reaction Details |
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Target | Collagenase 3 |
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Ligand | BDBM50194289 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_458357 (CHEMBL941691) |
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IC50 | 0.68±n/a nM |
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Citation | Freeman-Cook, KD; Reiter, LA; Noe, MC; Antipas, AS; Danley, DE; Datta, K; Downs, JT; Eisenbeis, S; Eskra, JD; Garmene, DJ; Greer, EM; Griffiths, RJ; Guzman, R; Hardink, JR; Janat, F; Jones, CS; Martinelli, GJ; Mitchell, PG; Laird, ER; Liras, JL; Lopresti-Morrow, LL; Pandit, J; Reilly, UD; Robertson, D; Vaughn-Bowser, ML; Wolf-Gouviea, LA; Yocum, SA Potent, selective spiropyrrolidine pyrimidinetrione inhibitors of MMP-13. Bioorg Med Chem Lett17:6529-34 (2007) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Collagenase 3 |
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Name: | Collagenase 3 |
Synonyms: | MMP-13 | MMP13 | MMP13_HUMAN | Matrix metalloproteinase-13 | Matrix metalloproteinase-13 (MMP-13) | Matrix metalloproteinase-13 (MMP13) |
Type: | Enzyme |
Mol. Mass.: | 53808.06 |
Organism: | Homo sapiens (Human) |
Description: | P45452 |
Residue: | 471 |
Sequence: | MHPGVLAAFLFLSWTHCRALPLPSGGDEDDLSEEDLQFAERYLRSYYHPTNLAGILKENA
ASSMTERLREMQSFFGLEVTGKLDDNTLDVMKKPRCGVPDVGEYNVFPRTLKWSKMNLTY
RIVNYTPDMTHSEVEKAFKKAFKVWSDVTPLNFTRLHDGIADIMISFGIKEHGDFYPFDG
PSGLLAHAFPPGPNYGGDAHFDDDETWTSSSKGYNLFLVAAHEFGHSLGLDHSKDPGALM
FPIYTYTGKSHFMLPDDDVQGIQSLYGPGDEDPNPKHPKTPDKCDPSLSLDAITSLRGET
MIFKDRFFWRLHPQQVDAELFLTKSFWPELPNRIDAAYEHPSHDLIFIFRGRKFWALNGY
DILEGYPKKISELGLPKEVKKISAAVHFEDTGKTLLFSGNQVWRYDDTNHIMDKDYPRLI
EEDFPGIGDKVDAVYEKNGYIYFFNGPIQFEYSIWSNRIVRVMPANSILWC
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BDBM50194289 |
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n/a |
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Name | BDBM50194289 |
Synonyms: | 5-(2-ethoxy-ethyl)-5-(4-{4-[4-(4-fluoro-phenyl)-oxazol-2-yl]-phenoxy}-phenoxy)-pyrimidine-2,4,6-trione | 5-(2-ethoxyethyl)-5-(4-(4-(4-(4-fluorophenyl)oxazol-2-yl)phenoxy)phenoxy)pyrimidine-2,4,6(1H,3H,5H)-trione | CHEMBL220957 |
Type | Small organic molecule |
Emp. Form. | C29H24FN3O7 |
Mol. Mass. | 545.5152 |
SMILES | CCOCCC1(Oc2ccc(Oc3ccc(cc3)-c3nc(co3)-c3ccc(F)cc3)cc2)C(=O)NC(=O)NC1=O |
Structure |
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