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| Reaction Details | |||
|---|---|---|---|
 | Report a problem with these data | ||
| Target | Serine/threonine-protein kinase Chk2 | ||
| Ligand | BDBM50225005 | ||
| Substrate/Competitor | n/a | ||
| Meas. Tech. | ChEMBL_458529 (CHEMBL942788) | ||
| IC50 | 35±n/a nM | ||
| Citation |  Neff, DK; Lee-Dutra, A; Blevitt, JM; Axe, FU; Hack, MD; Buma, JC; Rynberg, R; Brunmark, A; Karlsson, L; Breitenbucher, JG 2-Aryl benzimidazoles featuring alkyl-linked pendant alcohols and amines as inhibitors of checkpoint kinase Chk2. Bioorg Med Chem Lett17:6467-71 (2007) [PubMed] Article | ||
| More Info.: | Get all data from this article, Assay Method | ||
| Serine/threonine-protein kinase Chk2 | |||
| Name: | Serine/threonine-protein kinase Chk2 | ||
| Synonyms: | CDS1 | CHEK2 | CHK2 | CHK2_HUMAN | Checkpoint Kinase (Chk2) | RAD53 | Serine/threonine-protein kinase Chek2 | Serine/threonine-protein kinase Chk1/2 | ||
| Type: | Protein | ||
| Mol. Mass.: | 60908.59 | ||
| Organism: | Homo sapiens (Human) | ||
| Description: | O96017 | ||
| Residue: | 543 | ||
| Sequence: |
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| BDBM50225005 | |||
| n/a | |||
| Name | BDBM50225005 | ||
| Synonyms: | 2-(4-((1s,4s)-4-(hydroxymethyl)cyclohexyloxy)phenyl)-1H-benzo[d]imidazole-5-carboxamide | CHEMBL249570 | ||
| Type | Small organic molecule | ||
| Emp. Form. | C21H23N3O3 | ||
| Mol. Mass. | 365.4256 | ||
| SMILES | NC(=O)c1ccc2nc([nH]c2c1)-c1ccc(O[C@@H]2CC[C@H](CO)CC2)cc1 |wU:17.18,20.22,(-8.66,-18.67,;-7.34,-17.9,;-7.34,-16.37,;-5.99,-18.68,;-5.99,-20.21,;-4.65,-20.98,;-3.33,-20.21,;-1.87,-20.69,;-.97,-19.45,;-1.87,-18.2,;-3.33,-18.67,;-4.65,-17.91,;.57,-19.53,;1.3,-20.9,;2.84,-20.96,;3.67,-19.64,;5.2,-19.69,;6,-18.37,;7.55,-18.41,;8.33,-17.09,;7.61,-15.73,;8.42,-14.42,;9.95,-14.47,;6.06,-15.69,;5.26,-17.01,;2.95,-18.3,;1.4,-18.24,)| | ||
| Structure | 
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