Reaction Details |
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Target | P2X purinoceptor 7 |
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Ligand | BDBM50411428 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_451545 (CHEMBL900721) |
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IC50 | 631±n/a nM |
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Citation | Furber, M; Alcaraz, L; Bent, JE; Beyerbach, A; Bowers, K; Braddock, M; Caffrey, MV; Cladingboel, D; Collington, J; Donald, DK; Fagura, M; Ince, F; Kinchin, EC; Laurent, C; Lawson, M; Luker, TJ; Mortimore, MM; Pimm, AD; Riley, RJ; Roberts, N; Robertson, M; Theaker, J; Thorne, PV; Weaver, R; Webborn, P; Willis, P Discovery of potent and selective adamantane-based small-molecule P2X(7) receptor antagonists/interleukin-1beta inhibitors. J Med Chem50:5882-5 (2007) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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P2X purinoceptor 7 |
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Name: | P2X purinoceptor 7 |
Synonyms: | ATP receptor | P2RX7_RAT | P2X purinoceptor 7 | P2X purinoceptor 7 (P2RX7) | P2X purinoceptor 7 (P2X7) | P2X7 | P2X7 rat | P2Z receptor | P2rx7 | Purinergic receptor |
Type: | Protein |
Mol. Mass.: | 68403.50 |
Organism: | Rattus norvegicus (Rat) |
Description: | Q64663 |
Residue: | 595 |
Sequence: | MPACCSWNDVFQYETNKVTRIQSVNYGTIKWILHMTVFSYVSFALMSDKLYQRKEPLISS
VHTKVKGVAEVTENVTEGGVTKLVHGIFDTADYTLPLQGNSFFVMTNYLKSEGQEQKLCP
EYPSRGKQCHSDQGCIKGWMDPQSKGIQTGRCIPYDQKRKTCEIFAWCPAEEGKEAPRPA
LLRSAENFTVLIKNNIDFPGHNYTTRNILPGMNISCTFHKTWNPQCPIFRLGDIFQEIGE
NFTEVAVQGGIMGIEIYWDCNLDSWSHRCQPKYSFRRLDDKYTNESLFPGYNFRYAKYYK
ENGMEKRTLIKAFGVRFDILVFGTGGKFDIIQLVVYIGSTLSYFGLATVCIDLIINTYAS
TCCRSRVYPSCKCCEPCAVNEYYYRKKCEPIVEPKPTLKYVSFVDEPHIWMVDQQLLGKS
LQDVKGQEVPRPQTDFLELSRLSLSLHHSPPIPGQPEEMQLLQIEAVPRSRDSPDWCQCG
NCLPSQLPENRRALEELCCRRKPGQCITTSELFSKIVLSREALQLLLLYQEPLLALEGEA
INSKLRHCAYRSYATWRFVSQDMADFAILPSCCRWKIRKEFPKTQGQYSGFKYPY
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BDBM50411428 |
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n/a |
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Name | BDBM50411428 |
Synonyms: | CHEMBL393384 |
Type | Small organic molecule |
Emp. Form. | C23H31ClN2O2 |
Mol. Mass. | 402.957 |
SMILES | Clc1ccc(OC2CCNCC2)cc1C(=O)NCC12CC3CC(CC(C3)C1)C2 |TLB:17:18:21:25.23.24,THB:23:22:19:25.24.26,23:24:21.22.27:19,26:24:21:27.18.19,26:18:21:25.23.24| |
Structure |
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