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TargetP2X purinoceptor 7 (P2X7)
LigandBDBM50411430
Substrate/Competitorn/a
Meas. Tech.ChEMBL_451545
IC50 794±n/a nM
Citation Furber MAlcaraz LBent JEBeyerbach ABowers KBraddock MCaffrey MVCladingboel DCollington JDonald DKFagura MInce FKinchin ECLaurent CLawson MLuker TJMortimore MMPimm ADRiley RJRoberts NRobertson MTheaker JThorne PVWeaver RWebborn PWillis P Discovery of potent and selective adamantane-based small-molecule P2X(7) receptor antagonists/interleukin-1beta inhibitors. J Med Chem 50:5882-5 (2007) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
P2X purinoceptor 7 (P2X7)
Name:P2X purinoceptor 7
Synonyms:ATP receptor | P2X purinoceptor 7 | P2X purinoceptor 7 (P2RX7) | P2X7 | P2Z receptor | Purinergic receptor
Type:Protein
Mol. Mass.:68403.50
Organism:Rattus norvegicus (Rat)
Description:Q64663
Residue:595
Sequence:
MPACCSWNDVFQYETNKVTRIQSVNYGTIKWILHMTVFSYVSFALMSDKLYQRKEPLISS
VHTKVKGVAEVTENVTEGGVTKLVHGIFDTADYTLPLQGNSFFVMTNYLKSEGQEQKLCP
EYPSRGKQCHSDQGCIKGWMDPQSKGIQTGRCIPYDQKRKTCEIFAWCPAEEGKEAPRPA
LLRSAENFTVLIKNNIDFPGHNYTTRNILPGMNISCTFHKTWNPQCPIFRLGDIFQEIGE
NFTEVAVQGGIMGIEIYWDCNLDSWSHRCQPKYSFRRLDDKYTNESLFPGYNFRYAKYYK
ENGMEKRTLIKAFGVRFDILVFGTGGKFDIIQLVVYIGSTLSYFGLATVCIDLIINTYAS
TCCRSRVYPSCKCCEPCAVNEYYYRKKCEPIVEPKPTLKYVSFVDEPHIWMVDQQLLGKS
LQDVKGQEVPRPQTDFLELSRLSLSLHHSPPIPGQPEEMQLLQIEAVPRSRDSPDWCQCG
NCLPSQLPENRRALEELCCRRKPGQCITTSELFSKIVLSREALQLLLLYQEPLLALEGEA
INSKLRHCAYRSYATWRFVSQDMADFAILPSCCRWKIRKEFPKTQGQYSGFKYPY
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM50411430
n/a
NameBDBM50411430
Synonyms:CHEMBL235791
TypeSmall organic molecule
Emp. Form.C24H33ClN2O
Mol. Mass.400.985
SMILESClc1cc(CN2CCCCC2)ccc1C(=O)NCC12CC3CC(CC(C3)C1)C2 |TLB:17:18:21:25.23.24,THB:23:22:19:25.24.26,23:24:21.22.27:19,26:24:21:27.18.19,26:18:21:25.23.24|
Structure
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