| Reaction Details |
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 | Report a problem with these data |
| Target | Farnesyl pyrophosphate synthase |
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| Ligand | BDBM50225572 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_451566 (CHEMBL901776) |
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| IC50 | 7943±n/a nM |
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| Citation |  Zhang, Y; Hudock, MP; Krysiak, K; Cao, R; Bergan, K; Yin, F; Leon, A; Oldfield, E Activity of sulfonium bisphosphonates on tumor cell lines. J Med Chem50:6067-79 (2007) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Farnesyl pyrophosphate synthase |
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| Name: | Farnesyl pyrophosphate synthase |
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| Synonyms: | Dimethylallyltranstransferase | FDPS | FPP synthase | FPP synthetase | FPPS_HUMAN | FPS | Farnesyl diphosphate synthase | Farnesyl diphosphate synthase (FPPS) | Farnesyl diphosphate synthetase | Farnesyl pyrophosphate synthase (FPPS) | Farnesyl pyrophosphate synthetase | Geranyltranstransferase | KIAA1293 | P14324 |
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| Type: | Enzyme |
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| Mol. Mass.: | 48272.89 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P14324 |
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| Residue: | 419 |
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| Sequence: | MPLSRWLRSVGVFLLPAPYWAPRERWLGSLRRPSLVHGYPVLAWHSARCWCQAWTEEPRA
LCSSLRMNGDQNSDVYAQEKQDFVQHFSQIVRVLTEDEMGHPEIGDAIARLKEVLEYNAI
GGKYNRGLTVVVAFRELVEPRKQDADSLQRAWTVGWCVELLQAFFLVADDIMDSSLTRRG
QICWYQKPGVGLDAINDANLLEACIYRLLKLYCREQPYYLNLIELFLQSSYQTEIGQTLD
LLTAPQGNVDLVRFTEKRYKSIVKYKTAFYSFYLPIAAAMYMAGIDGEKEHANAKKILLE
MGEFFQIQDDYLDLFGDPSVTGKIGTDIQDNKCSWLVVQCLQRATPEQYQILKENYGQKE
AEKVARVKALYEELDLPAVFLQYEEDSYSHIMALIEQYAAPLPPAVFLGLARKIYKRRK
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| BDBM50225572 |
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| n/a |
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| Name | BDBM50225572 |
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| Synonyms: | 2-(methyl, octadecylsulfonium-1-yl)ethylidene-1,1-bisphosphonic acid | CHEMBL398105 |
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| Type | Small organic molecule |
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| Emp. Form. | C21H46O6P2S |
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| Mol. Mass. | 488.599 |
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| SMILES | CCCCCCCCCCCCCCCCCC[S+](C)CC(P(O)(O)=O)P(O)([O-])=O |
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| Structure | 
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