| Reaction Details |
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 | Report a problem with these data |
| Target | Substance-P receptor |
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| Ligand | BDBM50225898 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_451685 (CHEMBL901897) |
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| IC50 | 3.4±n/a nM |
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| Citation |  Shishido, Y; Ito, F; Morita, H; Ikunaka, M Stereoselective synthesis of a novel 2-aza-7-oxabicyclo[3.3.0]octane as neurokinin-1 receptor antagonist. Bioorg Med Chem Lett17:6887-90 (2007) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Substance-P receptor |
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| Name: | Substance-P receptor |
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| Synonyms: | NK-1 receptor | NK-1R | NK1 Receptor | NK1R | NK1R_HUMAN | Neurokinin 1 receptor | Neurokinin-1 (NK-1) | Neuromedin-1 receptor (NK-1R) | SPR | TAC1R | TACR1 | Tachykinin receptor 1 | Tachykinin receptor 1 (NK1) | tachykinin |
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| Type: | G Protein-Coupled Receptor (GPCR) |
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| Mol. Mass.: | 46254.43 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P25103 |
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| Residue: | 407 |
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| Sequence: | MDNVLPVDSDLSPNISTNTSEPNQFVQPAWQIVLWAAAYTVIVVTSVVGNVVVMWIILAH
KRMRTVTNYFLVNLAFAEASMAAFNTVVNFTYAVHNEWYYGLFYCKFHNFFPIAAVFASI
YSMTAVAFDRYMAIIHPLQPRLSATATKVVICVIWVLALLLAFPQGYYSTTETMPSRVVC
MIEWPEHPNKIYEKVYHICVTVLIYFLPLLVIGYAYTVVGITLWASEIPGDSSDRYHEQV
SAKRKVVKMMIVVVCTFAICWLPFHIFFLLPYINPDLYLKKFIQQVYLAIMWLAMSSTMY
NPIIYCCLNDRFRLGFKHAFRCCPFISAGDYEGLEMKSTRYLQTQGSVYKVSRLETTIST
VVGAHEEEPEDGPKATPSSLDLTSNCSSRSDSKTMTESFSFSSNVLS
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| BDBM50225898 |
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| n/a |
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| Name | BDBM50225898 |
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| Synonyms: | (2-Methoxy-benzyl)-((2S,3S,3aR,6aS)-2-phenyl-octahydro-cyclopenta[b]pyrrol-3-yl)-amine | (2S,3S,3aR,6aS)-N-(2-methoxybenzyl)-2-phenyl-octahydrocyclopenta[b]pyrrol-3-amine | CHEMBL55591 |
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| Type | Small organic molecule |
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| Emp. Form. | C21H26N2O |
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| Mol. Mass. | 322.4439 |
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| SMILES | COc1ccccc1CN[C@H]1[C@@H]2CCC[C@@H]2N[C@H]1c1ccccc1 |
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| Structure | 
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