| Reaction Details |
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 | Report a problem with these data |
| Target | Farnesyl pyrophosphate synthase |
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| Ligand | BDBM50225999 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_451825 (CHEMBL902037) |
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| IC50 | 16.4±n/a nM |
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| Citation |  Marma, MS; Xia, Z; Stewart, C; Coxon, F; Dunford, JE; Baron, R; Kashemirov, BA; Ebetino, FH; Triffitt, JT; Russell, RG; McKenna, CE Synthesis and biological evaluation of alpha-halogenated bisphosphonate and phosphonocarboxylate analogues of risedronate. J Med Chem50:5967-75 (2007) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Farnesyl pyrophosphate synthase |
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| Name: | Farnesyl pyrophosphate synthase |
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| Synonyms: | Dimethylallyltranstransferase | FDPS | FPP synthase | FPP synthetase | FPPS_HUMAN | FPS | Farnesyl diphosphate synthase | Farnesyl diphosphate synthase (FPPS) | Farnesyl diphosphate synthetase | Farnesyl pyrophosphate synthase (FPPS) | Farnesyl pyrophosphate synthetase | Geranyltranstransferase | KIAA1293 | P14324 |
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| Type: | Enzyme |
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| Mol. Mass.: | 48272.89 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P14324 |
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| Residue: | 419 |
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| Sequence: | MPLSRWLRSVGVFLLPAPYWAPRERWLGSLRRPSLVHGYPVLAWHSARCWCQAWTEEPRA
LCSSLRMNGDQNSDVYAQEKQDFVQHFSQIVRVLTEDEMGHPEIGDAIARLKEVLEYNAI
GGKYNRGLTVVVAFRELVEPRKQDADSLQRAWTVGWCVELLQAFFLVADDIMDSSLTRRG
QICWYQKPGVGLDAINDANLLEACIYRLLKLYCREQPYYLNLIELFLQSSYQTEIGQTLD
LLTAPQGNVDLVRFTEKRYKSIVKYKTAFYSFYLPIAAAMYMAGIDGEKEHANAKKILLE
MGEFFQIQDDYLDLFGDPSVTGKIGTDIQDNKCSWLVVQCLQRATPEQYQILKENYGQKE
AEKVARVKALYEELDLPAVFLQYEEDSYSHIMALIEQYAAPLPPAVFLGLARKIYKRRK
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| BDBM50225999 |
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| n/a |
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| Name | BDBM50225999 |
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| Synonyms: | 1-fluoro-2-(3-pyridinyl)-ethylidene-1,1-bisphosphonic acid | CHEMBL437758 |
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| Type | Small organic molecule |
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| Emp. Form. | C7H10FNO6P2 |
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| Mol. Mass. | 285.1033 |
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| SMILES | OP(O)(=O)C(F)(Cc1cccnc1)P(O)(O)=O |
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| Structure | 
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