| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Farnesyl pyrophosphate synthase |
|---|
| Ligand | BDBM50226002 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_451825 (CHEMBL902037) |
|---|
| IC50 | 253500±n/a nM |
|---|
| Citation |  Marma, MS; Xia, Z; Stewart, C; Coxon, F; Dunford, JE; Baron, R; Kashemirov, BA; Ebetino, FH; Triffitt, JT; Russell, RG; McKenna, CE Synthesis and biological evaluation of alpha-halogenated bisphosphonate and phosphonocarboxylate analogues of risedronate. J Med Chem50:5967-75 (2007) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Farnesyl pyrophosphate synthase |
|---|
| Name: | Farnesyl pyrophosphate synthase |
|---|
| Synonyms: | Dimethylallyltranstransferase | FDPS | FPP synthase | FPP synthetase | FPPS_HUMAN | FPS | Farnesyl diphosphate synthase | Farnesyl diphosphate synthase (FPPS) | Farnesyl diphosphate synthetase | Farnesyl pyrophosphate synthase (FPPS) | Farnesyl pyrophosphate synthetase | Geranyltranstransferase | KIAA1293 | P14324 |
|---|
| Type: | Enzyme |
|---|
| Mol. Mass.: | 48272.89 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | P14324 |
|---|
| Residue: | 419 |
|---|
| Sequence: | MPLSRWLRSVGVFLLPAPYWAPRERWLGSLRRPSLVHGYPVLAWHSARCWCQAWTEEPRA
LCSSLRMNGDQNSDVYAQEKQDFVQHFSQIVRVLTEDEMGHPEIGDAIARLKEVLEYNAI
GGKYNRGLTVVVAFRELVEPRKQDADSLQRAWTVGWCVELLQAFFLVADDIMDSSLTRRG
QICWYQKPGVGLDAINDANLLEACIYRLLKLYCREQPYYLNLIELFLQSSYQTEIGQTLD
LLTAPQGNVDLVRFTEKRYKSIVKYKTAFYSFYLPIAAAMYMAGIDGEKEHANAKKILLE
MGEFFQIQDDYLDLFGDPSVTGKIGTDIQDNKCSWLVVQCLQRATPEQYQILKENYGQKE
AEKVARVKALYEELDLPAVFLQYEEDSYSHIMALIEQYAAPLPPAVFLGLARKIYKRRK
|
|
|
|---|
| BDBM50226002 |
|---|
| n/a |
|---|
| Name | BDBM50226002 |
|---|
| Synonyms: | (R)-2-hydroxy-2-phosphono-3-(pyridin-3-yl)propanoic acid | 2-hydroxy-2-phosphono-3-(pyridin-3-yl)propanoic acid | 3-(3-Pyridyl)-2-hydroxy-2-phosphonopropanoic acid | CHEMBL397829 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C8H10NO6P |
|---|
| Mol. Mass. | 247.1419 |
|---|
| SMILES | OC(=O)C(O)(Cc1cccnc1)P(O)(O)=O |
|---|
| Structure | 
|
|---|
Search and Browse
