| Reaction Details |
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 | Report a problem with these data |
| Target | Histone deacetylase 1 |
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| Ligand | BDBM50226116 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_451853 (CHEMBL902067) |
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| IC50 | 100±n/a nM |
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| Citation |  Vaisburg, A; Paquin, I; Bernstein, N; Frechette, S; Gaudette, F; Leit, S; Moradei, O; Raeppel, S; Zhou, N; Bouchain, G; Woo, SH; Jin, Z; Gillespie, J; Wang, J; Fournel, M; Yan, PT; Trachy-Bourget, MC; Robert, MF; Lu, A; Yuk, J; Rahil, J; Macleod, AR; Besterman, JM; Li, Z; Delorme, D N-(2-Amino-phenyl)-4-(heteroarylmethyl)-benzamides as new histone deacetylase inhibitors. Bioorg Med Chem Lett17:6729-33 (2007) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Histone deacetylase 1 |
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| Name: | Histone deacetylase 1 |
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| Synonyms: | Cereblon/Histone deacetylase 1 | HD1 | HDAC1 | HDAC1_HUMAN | Histone deacetylase 1 (HDAC1) | Human HDAC1 | RPD3L1 |
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| Type: | Enzyme |
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| Mol. Mass.: | 55090.27 |
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| Organism: | Homo sapiens (Human) |
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| Description: | Q13547 |
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| Residue: | 482 |
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| Sequence: | MAQTQGTRRKVCYYYDGDVGNYYYGQGHPMKPHRIRMTHNLLLNYGLYRKMEIYRPHKAN
AEEMTKYHSDDYIKFLRSIRPDNMSEYSKQMQRFNVGEDCPVFDGLFEFCQLSTGGSVAS
AVKLNKQQTDIAVNWAGGLHHAKKSEASGFCYVNDIVLAILELLKYHQRVLYIDIDIHHG
DGVEEAFYTTDRVMTVSFHKYGEYFPGTGDLRDIGAGKGKYYAVNYPLRDGIDDESYEAI
FKPVMSKVMEMFQPSAVVLQCGSDSLSGDRLGCFNLTIKGHAKCVEFVKSFNLPMLMLGG
GGYTIRNVARCWTYETAVALDTEIPNELPYNDYFEYFGPDFKLHISPSNMTNQNTNEYLE
KIKQRLFENLRMLPHAPGVQMQAIPEDAIPEESGDEDEDDPDKRISICSSDKRIACEEEF
SDSEEEGEGGRKNSSNFKKAKRVKTEDEKEKDPEEKKEVTEEEKTKEEKPEAKGVKEEVK
LA
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| BDBM50226116 |
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| n/a |
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| Name | BDBM50226116 |
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| Synonyms: | 4-((1-(4-methoxybenzyl)-2,4-dioxo-1,2-dihydroquinazolin-3(4H)-yl)methyl)-N-(2-aminophenyl)benzamide | CHEMBL241551 |
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| Type | Small organic molecule |
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| Emp. Form. | C30H26N4O4 |
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| Mol. Mass. | 506.5518 |
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| SMILES | COc1ccc(Cn2c3ccccc3c(=O)n(Cc3ccc(cc3)C(=O)Nc3ccccc3N)c2=O)cc1 |
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| Structure | 
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