Ki Summary BindingDB logo
myBDB logout
Reaction Details
Report a problem with these data
TargetCarboxypeptidase N catalytic chain
LigandBDBM50226600
Substrate/Competitorn/a
Meas. Tech.ChEMBL_452078 (CHEMBL901239)
Ki>10000±n/a nM
Citation Bunnage, ME; Blagg, J; Steele, J; Owen, DR; Allerton, C; McElroy, AB; Miller, D; Ringer, T; Butcher, K; Beaumont, K; Evans, K; Gray, AJ; Holland, SJ; Feeder, N; Moore, RS; Brown, DG Discovery of potent& selective inhibitors of activated thrombin-activatable fibrinolysis inhibitor for the treatment of thrombosis. J Med Chem50:6095-103 (2007) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Carboxypeptidase N catalytic chain
Name:Carboxypeptidase N catalytic chain
Synonyms:ACBP | Anaphylatoxin inactivator | Arginine carboxypeptidase | CBPN_HUMAN | CPN | CPN1 | Carboxypeptidase N catalytic chain | Carboxypeptidase N polypeptide 1 | Carboxypeptidase N small subunit | Carboxypeptidase N, catalytic subunit | Kininase-1 | Lysine carboxypeptidase | Plasma carboxypeptidase B | SCPN | Serum carboxypeptidase N
Type:PROTEIN
Mol. Mass.:52293.66
Organism:Homo sapiens (Human)
Description:ChEMBL_1496379
Residue:458
Sequence:
MSDLLSVFLHLLLLFKLVAPVTFRHHRYDDLVRTLYKVQNECPGITRVYSIGRSVEGRHL
YVLEFSDHPGIHEPLEPEVKYVGNMHGNEALGRELMLQLSEFLCEEFRNRNQRIVQLIQD
TRIHILPSMNPDGYEVAAAQGPNKPGYLVGRNNANGVDLNRNFPDLNTYIYYNEKYGGPN
HHLPLPDNWKSQVEPETRAVIRWMHSFNFVLSANLHGGAVVANYPYDKSFEHRVRGVRRT
ASTPTPDDKLFQKLAKVYSYAHGWMFQGWNCGDYFPDGITNGASWYSLSKGMQDFNYLHT
NCFEITLELSCDKFPPEEELQREWLGNREALIQFLEQVHQGIKGMVLDENYNNLANAVIS
VSGINHDVTSGDHGDYFRLLLPGIYTVSATAPGYDPETVTVTVGPAEPTLVNFHLKRSIP
QVSPVRRAPSRRHGVRAKVQPQARKKEMEMRQLQRGPA
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM50226600
n/a
NameBDBM50226600
Synonyms:(2S)-2-[(2-aminoethyl)amino]-3-(1H-imidazol-4-yl)propanoic acid | CHEMBL235697
TypeSmall organic molecule
Emp. Form.C8H14N4O2
Mol. Mass.198.2224
SMILESNCCN[C@@H](Cc1cnc[nH]1)C(O)=O
Structure
Search PDB for entries with ligand similarity:Similarity to this molecule at least: