Ki Summary new BindingDB logo
myBDB logout
Reaction Details
Report a problem with these data
TargetThrombin-activable fibrinolysis inhibitor (TAFIa)
LigandBDBM50226601
Substrate/Competitorn/a
Meas. Tech.ChEMBL_452077
Ki 235±n/a nM
Citation Bunnage MEBlagg JSteele JOwen DRAllerton CMcElroy ABMiller DRinger TButcher KBeaumont KEvans KGray AJHolland SJFeeder NMoore RSBrown DG Discovery of potent& selective inhibitors of activated thrombin-activatable fibrinolysis inhibitor for the treatment of thrombosis. J Med Chem 50:6095-103 (2007) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Thrombin-activable fibrinolysis inhibitor (TAFIa)
Name:Carboxypeptidase B2 isoform A
Synonyms:CPB2 | CPU | Carboxypeptidase B2 | Carboxypeptidase B2 isoform A | Carboxypeptidase U | Plasma carboxypeptidase B | TAFI | Thrombin-activable fibrinolysis inhibitor | pCPB
Type:Enzyme
Mol. Mass.:48432.74
Organism:Homo sapiens (Human)
Description:Q96IY4
Residue:423
Sequence:
MKLCSLAVLVPIVLFCEQHVFAFQSGQVLAALPRTSRQVQVLQNLTTTYEIVLWQPVTAD
LIVKKKQVHFFVNASDVDNVKAHLNVSGIPCSVLLADVEDLIQQQISNDTVSPRASASYY
EQYHSLNEIYSWIEFITERHPDMLTKIHIGSSFEKYPLYVLKVSGKEQAAKNAIWIDCGI
HAREWISPAFCLWFIGHITQFYGIIGQYTNLLRLVDFYVMPVVNVDGYDYSWKKNRMWRK
NRSFYANNHCIGTDLNRNFASKHWCEEGASSSSCSETYCGLYPESEPEVKAVASFLRRNI
NQIKAYISMHSYSQHIVFPYSYTRSKSKDHEELSLVASEAVRAIEKISKNTRYTHGHGSE
TLYLAPGGGDDWIYDLGIKYSFTIELRDTGTYGFLLPERYIKPTCREAFAAVSKIAWHVI
RNV
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM50226601
n/a
NameBDBM50226601
Synonyms:(2S)-2-[(2-aminoethyl)amino]-3-(1-methyl-1H-imidazol-4-yl)propanoic acid | CHEMBL235058
TypeSmall organic molecule
Emp. Form.C9H16N4O2
Mol. Mass.212.2489
SMILESCn1cnc(C[C@H](NCCN)C(O)=O)c1
Structure
Search PDB for entries with ligand similarity:Similarity to this molecule at least: