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TargetThrombin-activable fibrinolysis inhibitor (TAFIa)
LigandBDBM50226608
Substrate/Competitorn/a
Meas. Tech.ChEMBL_452077
Ki 269±n/a nM
Citation Bunnage MEBlagg JSteele JOwen DRAllerton CMcElroy ABMiller DRinger TButcher KBeaumont KEvans KGray AJHolland SJFeeder NMoore RSBrown DG Discovery of potent& selective inhibitors of activated thrombin-activatable fibrinolysis inhibitor for the treatment of thrombosis. J Med Chem 50:6095-103 (2007) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Thrombin-activable fibrinolysis inhibitor (TAFIa)
Name:Carboxypeptidase B2 isoform A
Synonyms:CPB2 | CPU | Carboxypeptidase B2 | Carboxypeptidase B2 isoform A | Carboxypeptidase U | Plasma carboxypeptidase B | TAFI | Thrombin-activable fibrinolysis inhibitor | pCPB
Type:Enzyme
Mol. Mass.:48432.74
Organism:Homo sapiens (Human)
Description:Q96IY4
Residue:423
Sequence:
MKLCSLAVLVPIVLFCEQHVFAFQSGQVLAALPRTSRQVQVLQNLTTTYEIVLWQPVTAD
LIVKKKQVHFFVNASDVDNVKAHLNVSGIPCSVLLADVEDLIQQQISNDTVSPRASASYY
EQYHSLNEIYSWIEFITERHPDMLTKIHIGSSFEKYPLYVLKVSGKEQAAKNAIWIDCGI
HAREWISPAFCLWFIGHITQFYGIIGQYTNLLRLVDFYVMPVVNVDGYDYSWKKNRMWRK
NRSFYANNHCIGTDLNRNFASKHWCEEGASSSSCSETYCGLYPESEPEVKAVASFLRRNI
NQIKAYISMHSYSQHIVFPYSYTRSKSKDHEELSLVASEAVRAIEKISKNTRYTHGHGSE
TLYLAPGGGDDWIYDLGIKYSFTIELRDTGTYGFLLPERYIKPTCREAFAAVSKIAWHVI
RNV
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  Blast E-value cutoff:
BDBM50226608
n/a
NameBDBM50226608
Synonyms:(S)-2-(2-aminoethylamino)-3-(1-benzyl-1H-imidazol-4-yl)propanoic acid | CHEMBL236363
TypeSmall organic molecule
Emp. Form.C15H20N4O2
Mol. Mass.288.3449
SMILESNCCN[C@@H](Cc1cn(Cc2ccccc2)cn1)C(O)=O
Structure
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