| Reaction Details |
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 | Report a problem with these data |
| Target | C-X-C chemokine receptor type 1 |
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| Ligand | BDBM50227012 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_461467 (CHEMBL927477) |
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| Ki | 5950±n/a nM |
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| Citation |  Biju, P; Taveras, A; Yu, Y; Zheng, J; Chao, J; Rindgen, D; Jakway, J; Hipkin, RW; Fossetta, J; Fan, X; Fine, J; Qiu, H; Merritt, JR; Baldwin, JJ 3,4-Diamino-2,5-thiadiazole-1-oxides as potent CXCR2/CXCR1 antagonists. Bioorg Med Chem Lett18:228-31 (2008) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| C-X-C chemokine receptor type 1 |
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| Name: | C-X-C chemokine receptor type 1 |
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| Synonyms: | C-X-C chemokine receptor type 1 (CXCR-1) | C-X-C chemokine receptor type 1 (CXCR1) | CMKAR1 | CXCR1 | CXCR1_HUMAN | IL8RA | Interleukin-8 receptor A | Interleukin-8 receptors, CXCR1/CXCR2 |
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| Type: | Enzyme |
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| Mol. Mass.: | 39803.83 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P25024 |
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| Residue: | 350 |
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| Sequence: | MSNITDPQMWDFDDLNFTGMPPADEDYSPCMLETETLNKYVVIIAYALVFLLSLLGNSLV
MLVILYSRVGRSVTDVYLLNLALADLLFALTLPIWAASKVNGWIFGTFLCKVVSLLKEVN
FYSGILLLACISVDRYLAIVHATRTLTQKRHLVKFVCLGCWGLSMNLSLPFFLFRQAYHP
NNSSPVCYEVLGNDTAKWRMVLRILPHTFGFIVPLFVMLFCYGFTLRTLFKAHMGQKHRA
MRVIFAVVLIFLLCWLPYNLVLLADTLMRTQVIQESCERRNNIGRALDATEILGFLHSCL
NPIIYAFIGQNFRHGFLKILAMHGLVSKEFLARHRVTSYTSSSVNVSSNL
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| BDBM50227012 |
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| n/a |
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| Name | BDBM50227012 |
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| Synonyms: | 2-hydroxy-N,N-dimethyl-3-{4-[(R)-1-(5-methyl-furan-2-yl)-propylamino]-1,1-dioxo-1H-1lambda6-[1,2,5]thiadiazol-3-ylamino}-benzamide | CHEMBL253496 |
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| Type | Small organic molecule |
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| Emp. Form. | C19H23N5O5S |
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| Mol. Mass. | 433.481 |
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| SMILES | CC[C@@H](NC1=NS(=O)(=O)NC1=Nc1cccc(C(=O)N(C)C)c1O)c1ccc(C)o1 |w:11.12,t:4| |
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| Structure | 
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