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TargetC-X-C chemokine receptor type 1
LigandBDBM50227013
Substrate/Competitorn/a
Meas. Tech.ChEMBL_461467
Ki 2800±n/a nM
Citation Biju PTaveras AYu YZheng JChao JRindgen DJakway JHipkin RWFossetta JFan XFine JQiu HMerritt JRBaldwin JJ 3,4-Diamino-2,5-thiadiazole-1-oxides as potent CXCR2/CXCR1 antagonists. Bioorg Med Chem Lett 18:228-31 (2008) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
C-X-C chemokine receptor type 1
Name:C-X-C chemokine receptor type 1
Synonyms:C-X-C chemokine receptor type 1 (CXCR-1) | C-X-C chemokine receptor type 1 (CXCR1) | Interleukin-8 receptor A | Interleukin-8 receptors, CXCR1/CXCR2
Type:Enzyme
Mol. Mass.:39803.83
Organism:Homo sapiens (Human)
Description:P25024
Residue:350
Sequence:
MSNITDPQMWDFDDLNFTGMPPADEDYSPCMLETETLNKYVVIIAYALVFLLSLLGNSLV
MLVILYSRVGRSVTDVYLLNLALADLLFALTLPIWAASKVNGWIFGTFLCKVVSLLKEVN
FYSGILLLACISVDRYLAIVHATRTLTQKRHLVKFVCLGCWGLSMNLSLPFFLFRQAYHP
NNSSPVCYEVLGNDTAKWRMVLRILPHTFGFIVPLFVMLFCYGFTLRTLFKAHMGQKHRA
MRVIFAVVLIFLLCWLPYNLVLLADTLMRTQVIQESCERRNNIGRALDATEILGFLHSCL
NPIIYAFIGQNFRHGFLKILAMHGLVSKEFLARHRVTSYTSSSVNVSSNL
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  Blast E-value cutoff:
BDBM50227013
n/a
NameBDBM50227013
Synonyms:2-hydroxy-N,N-dimethyl-3-{4-[(R)-1-(4-methyl-3,4-dihydro-2H-benzo[1,4]oxazin-7-yl)-propylamino]-1,1-dioxo-1H-1lambda6-[1,2,5]thiadiazol-3-ylamino}-benzamide | CHEMBL252289
TypeSmall organic molecule
Emp. Form.C23H28N6O5S
Mol. Mass.500.571
SMILESCC[C@@H](NC1=NS(=O)(=O)NC1=Nc1cccc(C(=O)N(C)C)c1O)c1ccc2N(C)CCOc2c1 |w:11.12,t:4|
Structure
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