| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Phenylethanolamine N-methyltransferase |
|---|
| Ligand | BDBM50174121 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_461583 (CHEMBL927606) |
|---|
| Ki | 17±n/a nM |
|---|
| Citation |  Grunewald, GL; Seim, MR; Bhat, SR; Wilson, ME; Criscione, KR Synthesis of 4,5,6,7-tetrahydrothieno[3,2-c]pyridines and comparison with their isosteric 1,2,3,4-tetrahydroisoquinolines as inhibitors of phenylethanolamine N-methyltransferase. Bioorg Med Chem16:542-59 (2008) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Phenylethanolamine N-methyltransferase |
|---|
| Name: | Phenylethanolamine N-methyltransferase |
|---|
| Synonyms: | Noradrenaline N-methyltransferase | PENT | PNMT | PNMT_HUMAN | PNMTase | Phenylethanolamine N-Methyltransferase (PNMT) |
|---|
| Type: | Enzyme |
|---|
| Mol. Mass.: | 30852.66 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | n/a |
|---|
| Residue: | 282 |
|---|
| Sequence: | MSGADRSPNAGAAPDSAPGQAAVASAYQRFEPRAYLRNNYAPPRGDLCNPNGVGPWKLRC
LAQTFATGEVSGRTLIDIGSGPTVYQLLSACSHFEDITMTDFLEVNRQELGRWLQEEPGA
FNWSMYSQHACLIEGKGECWQDKERQLRARVKRVLPIDVHQPQPLGAGSPAPLPADALVS
AFCLEAVSPDLASFQRALDHITTLLRPGGHLLLIGALEESWYLAGEARLTVVPVSEEEVR
EALVRSGYKVRDLRTYIMPAHLQTGVDDVKGVFFAWAQKVGL
|
|
|
|---|
| BDBM50174121 |
|---|
| n/a |
|---|
| Name | BDBM50174121 |
|---|
| Synonyms: | 7-bromo-3-methyl-1,2,3,4-tetrahydroisoquinoline | 7-bromo-3-methyl-1,2,3,4-tetrahydroisoquinolinef | CHEMBL200375 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C10H12BrN |
|---|
| Mol. Mass. | 226.113 |
|---|
| SMILES | CC1Cc2ccc(Br)cc2CN1 |
|---|
| Structure | 
|
|---|
Search and Browse
