| Reaction Details |
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 | Report a problem with these data |
| Target | Phenylethanolamine N-methyltransferase |
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| Ligand | BDBM50072977 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_461584 (CHEMBL927607) |
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| Ki | 56±n/a nM |
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| Citation |  Grunewald, GL; Seim, MR; Bhat, SR; Wilson, ME; Criscione, KR Synthesis of 4,5,6,7-tetrahydrothieno[3,2-c]pyridines and comparison with their isosteric 1,2,3,4-tetrahydroisoquinolines as inhibitors of phenylethanolamine N-methyltransferase. Bioorg Med Chem16:542-59 (2008) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Phenylethanolamine N-methyltransferase |
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| Name: | Phenylethanolamine N-methyltransferase |
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| Synonyms: | Noradrenaline N-methyltransferase | PNMT | PNMT_BOVIN | PNMTase |
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| Type: | Enzyme |
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| Mol. Mass.: | 30916.97 |
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| Organism: | Bos taurus (bovine) |
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| Description: | n/a |
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| Residue: | 283 |
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| Sequence: | MSGTDRSQAAGAVPDSDPGLAAVSSAYQRFEPRAYLRNNYAPPRGDLSCPDGVGPWKLRC
LAQTFATGEVSGRTLIDIGSGPTIYQLLSACAHFEDITMTDFLEVNRQELRLWLREEPGA
FDWSVYSQHVCLIEGKGESWQEKECQLRARVKRILPIDVHRPQPLGAGGLAPLPADALVS
AFCLEAVSPDLASFQRALDHITTLLRPGGHLLLIGALEESWYLAGEARLAVVPVREEEVR
EALVRTATRCGICARTPMPAHLQTGVDDVKGIFFTRAQKKVGV
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| BDBM50072977 |
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| n/a |
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| Name | BDBM50072977 |
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| Synonyms: | 7-Bromo-1,2,3,4-tetrahydro-isoquinoline | 7-bromo-1,2,3,4-tetrahydroisoquinoline | CHEMBL281864 |
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| Type | Small organic molecule |
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| Emp. Form. | C9H10BrN |
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| Mol. Mass. | 212.086 |
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| SMILES | Brc1ccc2CCNCc2c1 |
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| Structure | 
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