| Reaction Details |
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 | Report a problem with these data |
| Target | Hydroxycarboxylic acid receptor 2 |
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| Ligand | BDBM23515 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_460001 (CHEMBL944044) |
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| IC50 | 140±n/a nM |
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| Citation |  Shen, HC; Szymonifka, MJ; Kharbanda, D; Deng, Q; Carballo-Jane, E; Wu, KK; Wu, TJ; Cheng, K; Ren, N; Cai, TQ; Taggart, AK; Wang, J; Tong, X; Waters, MG; Hammond, ML; Tata, JR; Colletti, SL Discovery of orally bioavailable and novel urea agonists of the high affinity niacin receptor GPR109A. Bioorg Med Chem Lett17:6723-8 (2008) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Hydroxycarboxylic acid receptor 2 |
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| Name: | Hydroxycarboxylic acid receptor 2 |
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| Synonyms: | G-protein coupled receptor 109A | G-protein coupled receptor HM74A | GPR109A | HCA2 | HCAR2 | HCAR2_HUMAN | HM74A | Hydroxycarboxylic acid receptor 2 | NIACR1 | Niacin Receptor GPR109A | Nicotinic acid receptor 1 |
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| Type: | G Protein-Coupled Receptor (GPCR) |
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| Mol. Mass.: | 41868.22 |
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| Organism: | Homo sapiens (Human) |
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| Description: | Membranes from CHO cells expressing the recombinant human GPR109A were used in competition binding assay. |
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| Residue: | 363 |
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| Sequence: | MNRHHLQDHFLEIDKKNCCVFRDDFIVKVLPPVLGLEFIFGLLGNGLALWIFCFHLKSWK
SSRIFLFNLAVADFLLIICLPFLMDNYVRRWDWKFGDIPCRLMLFMLAMNRQGSIIFLTV
VAVDRYFRVVHPHHALNKISNRTAAIISCLLWGITIGLTVHLLKKKMPIQNGGANLCSSF
SICHTFQWHEAMFLLEFFLPLGIILFCSARIIWSLRQRQMDRHAKIKRAITFIMVVAIVF
VICFLPSVVVRIRIFWLLHTSGTQNCEVYRSVDLAFFITLSFTYMNSMLDPVVYYFSSPS
FPNFFSTLINRCLQRKMTGEPDNNRSTSVELTGDPNKTRGAPEALMANSGEPWSPSYLGP
TSP
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| BDBM23515 |
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| n/a |
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| Name | BDBM23515 |
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| Synonyms: | CHEMBL573 | Niacin | Nicotinic Acid | [5, 6-3H]-niacin | pyridine-3-carboxylic acid | wampocap |
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| Type | Small organic molecule |
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| Emp. Form. | C6H5NO2 |
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| Mol. Mass. | 123.1094 |
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| SMILES | OC(=O)c1cccnc1 |
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| Structure | 
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