Reaction Details |
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Target | Disintegrin and metalloproteinase domain-containing protein 10 |
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Ligand | BDBM50203538 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_461662 (CHEMBL927683) |
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IC50 | 13±n/a nM |
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Citation | Yao, W; Zhuo, J; Burns, DM; Li, YL; Qian, DQ; Zhang, C; He, C; Xu, M; Shi, E; Li, Y; Marando, CA; Covington, MB; Yang, G; Liu, X; Pan, M; Fridman, JS; Scherle, P; Wasserman, ZR; Hollis, G; Vaddi, K; Yeleswaram, S; Newton, R; Friedman, S; Metcalf, B Design and identification of selective HER-2 sheddase inhibitors via P1' manipulation and unconventional P2' perturbations to induce a molecular metamorphosis. Bioorg Med Chem Lett18:159-63 (2008) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Disintegrin and metalloproteinase domain-containing protein 10 |
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Name: | Disintegrin and metalloproteinase domain-containing protein 10 |
Synonyms: | ADA10_HUMAN | ADAM10 | Disintegrin and metalloproteinase domain-containing protein 10 (ADAM10) | KUZ | MADM |
Type: | Enzyme |
Mol. Mass.: | 84160.93 |
Organism: | Homo sapiens (Human) |
Description: | O14672 |
Residue: | 748 |
Sequence: | MVLLRVLILLLSWAAGMGGQYGNPLNKYIRHYEGLSYNVDSLHQKHQRAKRAVSHEDQFL
RLDFHAHGRHFNLRMKRDTSLFSDEFKVETSNKVLDYDTSHIYTGHIYGEEGSFSHGSVI
DGRFEGFIQTRGGTFYVEPAERYIKDRTLPFHSVIYHEDDINYPHKYGPQGGCADHSVFE
RMRKYQMTGVEEVTQIPQEEHAANGPELLRKKRTTSAEKNTCQLYIQTDHLFFKYYGTRE
AVIAQISSHVKAIDTIYQTTDFSGIRNISFMVKRIRINTTADEKDPTNPFRFPNIGVEKF
LELNSEQNHDDYCLAYVFTDRDFDDGVLGLAWVGAPSGSSGGICEKSKLYSDGKKKSLNT
GIITVQNYGSHVPPKVSHITFAHEVGHNFGSPHDSGTECTPGESKNLGQKENGNYIMYAR
ATSGDKLNNNKFSLCSIRNISQVLEKKRNNCFVESGQPICGNGMVEQGEECDCGYSDQCK
DECCFDANQPEGRKCKLKPGKQCSPSQGPCCTAQCAFKSKSEKCRDDSDCAREGICNGFT
ALCPASDPKPNFTDCNRHTQVCINGQCAGSICEKYGLEECTCASSDGKDDKELCHVCCMK
KMDPSTCASTGSVQWSRHFSGRTITLQPGSPCNDFRGYCDVFMRCRLVDADGPLARLKKA
IFSPELYENIAEWIVAHWWAVLLMGIALIMLMAGFIKICSVHTPSSNPKLPPPKPLPGTL
KRRRPPQPIQQPQRQRPRESYQMGHMRR
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BDBM50203538 |
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n/a |
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Name | BDBM50203538 |
Synonyms: | (6S,7S)-6-(3-phenyl-2,5-dihydro-pyrrole-1-carbonyl)-5-aza-spiro[2.5]octane-7-carboxylic acid hydroxyamide | (6S,7S)-N-hydroxy-6-[(3-phenyl-2,5-dihydro-1H-pyrrol-1-yl)carbonyl]-5-azaspiro[2.5]octane-7-carboxamide | CHEMBL375418 |
Type | Small organic molecule |
Emp. Form. | C19H23N3O3 |
Mol. Mass. | 341.4042 |
SMILES | ONC(=O)[C@H]1CC2(CC2)CN[C@@H]1C(=O)N1CC=C(C1)c1ccccc1 |c:18| |
Structure |
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