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TargetCoagulation factor X
LigandBDBM50228932
Substrate/Competitorn/a
Meas. Tech.ChEMBL_461718
Ki 1.1±n/a nM
Citation Young RJBorthwick ADBrown DBurns-Kurtis CLCampbell MChan CCharbaut MChung CWConvery MAKelly HAPaul King NKleanthous SMason AMPateman AJPatikis ANPinto ILPollard DRSenger SShah GPToomey JRWatson NSWeston HE Structure and property based design of factor Xa inhibitors: pyrrolidin-2-ones with biaryl P4 motifs. Bioorg Med Chem Lett 18:23-7 (2008) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Coagulation factor X
Name:Thrombin and coagulation factor X
Synonyms:Activated coagulation factor X (FXa) | Activated factor Xa heavy chain | Coagulation factor X precursor | Coagulation factor Xa | F10 | Factor X heavy chain | Factor X light chain | Factor Xa | Stuart factor | Stuart-Prower factor
Type:Enzyme
Mol. Mass.:54726.60
Organism:Homo sapiens (Human)
Description:n/a
Residue:488
Sequence:
MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEE
TCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKN
CELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERR
KRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQE
CKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGE
AVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGI
VSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSG
GPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPE
VITSSPLK
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  Blast E-value cutoff:
BDBM50228932
n/a
NameBDBM50228932
Synonyms:6-chloro-N-(1-(2-fluoro-4-(1-methyl-1H-imidazol-2-yl)phenyl)-2-oxopyrrolidin-3-yl)naphthalene-2-sulfonamide | CHEMBL404218
TypeSmall organic molecule
Emp. Form.C24H20ClFN4O3S
Mol. Mass.498.957
SMILESCn1ccnc1-c1ccc(N2CCC(NS(=O)(=O)c3ccc4cc(Cl)ccc4c3)C2=O)c(F)c1 |w:13.14|
Structure
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