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TargetCoagulation factor X
LigandBDBM50228936
Substrate/Competitorn/a
Meas. Tech.ChEMBL_461718 (CHEMBL928849)
Ki 2.7±n/a nM
Citation Young, RJBorthwick, ADBrown, DBurns-Kurtis, CLCampbell, MChan, CCharbaut, MChung, CWConvery, MAKelly, HAPaul King, NKleanthous, SMason, AMPateman, AJPatikis, ANPinto, ILPollard, DRSenger, SShah, GPToomey, JRWatson, NSWeston, HE Structure and property based design of factor Xa inhibitors: pyrrolidin-2-ones with biaryl P4 motifs. Bioorg Med Chem Lett18:23-7 (2008) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Coagulation factor X
Name:Coagulation factor X
Synonyms:Activated coagulation factor X (FXa) | Activated factor Xa heavy chain | Coagulation factor X precursor | Coagulation factor Xa | F10 | FA10_HUMAN | Factor X heavy chain | Factor X light chain | Factor Xa | Stuart factor | Stuart-Prower factor
Type:Enzyme
Mol. Mass.:54726.60
Organism:Homo sapiens (Human)
Description:n/a
Residue:488
Sequence:
MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEE
TCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKN
CELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERR
KRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQE
CKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGE
AVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGI
VSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSG
GPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPE
VITSSPLK
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM50228936
n/a
NameBDBM50228936
Synonyms:6-chloro-N-(1-(2-fluoro-4-(1H-pyrazol-1-yl)phenyl)-2-oxopyrrolidin-3-yl)naphthalene-2-sulfonamide | CHEMBL404219
TypeSmall organic molecule
Emp. Form.C23H18ClFN4O3S
Mol. Mass.484.93
SMILESFc1cc(ccc1N1CCC(NS(=O)(=O)c2ccc3cc(Cl)ccc3c2)C1=O)-n1cccn1 |w:10.11|
Structure
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