Reaction Details |
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Target | Translocator protein |
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Ligand | BDBM50229593 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_460138 (CHEMBL924980) |
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Ki | 0.0978±n/a nM |
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Citation | Briard, E; Zoghbi, SS; Imaizumi, M; Gourley, JP; Shetty, HU; Hong, J; Cropley, V; Fujita, M; Innis, RB; Pike, VW Synthesis and evaluation in monkey of two sensitive 11C-labeled aryloxyanilide ligands for imaging brain peripheral benzodiazepine receptors in vivo. J Med Chem51:17-30 (2008) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Translocator protein |
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Name: | Translocator protein |
Synonyms: | Benzodiazepine receptors; peripheral & central | Bzrp | Mbr | Mitochondrial benzodiazepine receptor | PBR | PKBS | Peripheral benzodiazepine receptor (PBR) | Peripheral-Type Benzodiazepine Receptor | TSPO_RAT | Tspo |
Type: | Mitochondrion membrane protein |
Mol. Mass.: | 18945.84 |
Organism: | Rattus norvegicus (rat) |
Description: | Competitive binding experiments were performed on rat kidney mitochondrial membranes. |
Residue: | 169 |
Sequence: | MSQSWVPAVGLTLVPSLGGFMGAYFVRGEGLRWYASLQKPSWHPPRWTLAPIWGTLYSAM
GYGSYIIWKELGGFTEEAMVPLGLYTGQLALNWAWPPIFFGARQMGWALVDLMLVSGVAT
ATTLAWHRVSPPAARLLYPYLAWLAFATMLNYYVWRDNSGRRGGSRLTE
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BDBM50229593 |
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n/a |
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Name | BDBM50229593 |
Synonyms: | CHEMBL253596 | N-acetyl-N-(2-methoxycarbonylbenzyl)-2-phenoxyaniline |
Type | Small organic molecule |
Emp. Form. | C23H21NO4 |
Mol. Mass. | 375.4171 |
SMILES | COC(=O)c1ccccc1CN(C(C)=O)c1ccccc1Oc1ccccc1 |
Structure |
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