| Reaction Details |
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 | Report a problem with these data |
| Target | Disintegrin and metalloproteinase domain-containing protein 10 |
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| Ligand | BDBM50229655 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_461862 (CHEMBL927855) |
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| IC50 | 16±n/a nM |
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| Citation |  Burns, DM; He, C; Li, Y; Scherle, P; Liu, X; Marando, CA; Covington, MB; Yang, G; Pan, M; Turner, S; Fridman, JS; Hollis, G; Vaddi, K; Yeleswaram, S; Newton, R; Friedman, S; Metcalf, B; Yao, W Conversion of an MMP-potent scaffold to an MMP-selective HER-2 sheddase inhibitor via scaffold hybridization and subtle P1' permutations. Bioorg Med Chem Lett18:560-4 (2008) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Disintegrin and metalloproteinase domain-containing protein 10 |
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| Name: | Disintegrin and metalloproteinase domain-containing protein 10 |
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| Synonyms: | ADA10_HUMAN | ADAM10 | Disintegrin and metalloproteinase domain-containing protein 10 (ADAM10) | KUZ | MADM |
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| Type: | Enzyme |
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| Mol. Mass.: | 84160.93 |
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| Organism: | Homo sapiens (Human) |
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| Description: | O14672 |
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| Residue: | 748 |
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| Sequence: | MVLLRVLILLLSWAAGMGGQYGNPLNKYIRHYEGLSYNVDSLHQKHQRAKRAVSHEDQFL
RLDFHAHGRHFNLRMKRDTSLFSDEFKVETSNKVLDYDTSHIYTGHIYGEEGSFSHGSVI
DGRFEGFIQTRGGTFYVEPAERYIKDRTLPFHSVIYHEDDINYPHKYGPQGGCADHSVFE
RMRKYQMTGVEEVTQIPQEEHAANGPELLRKKRTTSAEKNTCQLYIQTDHLFFKYYGTRE
AVIAQISSHVKAIDTIYQTTDFSGIRNISFMVKRIRINTTADEKDPTNPFRFPNIGVEKF
LELNSEQNHDDYCLAYVFTDRDFDDGVLGLAWVGAPSGSSGGICEKSKLYSDGKKKSLNT
GIITVQNYGSHVPPKVSHITFAHEVGHNFGSPHDSGTECTPGESKNLGQKENGNYIMYAR
ATSGDKLNNNKFSLCSIRNISQVLEKKRNNCFVESGQPICGNGMVEQGEECDCGYSDQCK
DECCFDANQPEGRKCKLKPGKQCSPSQGPCCTAQCAFKSKSEKCRDDSDCAREGICNGFT
ALCPASDPKPNFTDCNRHTQVCINGQCAGSICEKYGLEECTCASSDGKDDKELCHVCCMK
KMDPSTCASTGSVQWSRHFSGRTITLQPGSPCNDFRGYCDVFMRCRLVDADGPLARLKKA
IFSPELYENIAEWIVAHWWAVLLMGIALIMLMAGFIKICSVHTPSSNPKLPPPKPLPGTL
KRRRPPQPIQQPQRQRPRESYQMGHMRR
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| BDBM50229655 |
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| n/a |
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| Name | BDBM50229655 |
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| Synonyms: | CHEMBL442432 | trans-2-hydroxycyclopentyl 4-(hydroxycarbamoyl)-4-((4-o-tolylpiperidin-1-ylsulfonyl)methyl)piperidine-1-carboxylate |
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| Type | Small organic molecule |
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| Emp. Form. | C25H37N3O7S |
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| Mol. Mass. | 523.642 |
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| SMILES | Cc1ccccc1C1CCN(CC1)S(=O)(=O)CC1(CCN(CC1)C(=O)OC1CCCC1O)C(=O)NO |w:26.28,30.34| |
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| Structure | 
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