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TargetDisintegrin and metalloproteinase domain-containing protein 10
LigandBDBM50229639
Substrate/Competitorn/a
Meas. Tech.ChEMBL_461861 (CHEMBL927854)
IC50 7.1±n/a nM
Citation Burns, DMHe, CLi, YScherle, PLiu, XMarando, CACovington, MBYang, GPan, MTurner, SFridman, JSHollis, GVaddi, KYeleswaram, SNewton, RFriedman, SMetcalf, BYao, W Conversion of an MMP-potent scaffold to an MMP-selective HER-2 sheddase inhibitor via scaffold hybridization and subtle P1' permutations. Bioorg Med Chem Lett18:560-4 (2008) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Disintegrin and metalloproteinase domain-containing protein 10
Name:Disintegrin and metalloproteinase domain-containing protein 10
Synonyms:ADA10_HUMAN | ADAM10 | Disintegrin and metalloproteinase domain-containing protein 10 (ADAM10) | KUZ | MADM
Type:Enzyme
Mol. Mass.:84160.93
Organism:Homo sapiens (Human)
Description:O14672
Residue:748
Sequence:
MVLLRVLILLLSWAAGMGGQYGNPLNKYIRHYEGLSYNVDSLHQKHQRAKRAVSHEDQFL
RLDFHAHGRHFNLRMKRDTSLFSDEFKVETSNKVLDYDTSHIYTGHIYGEEGSFSHGSVI
DGRFEGFIQTRGGTFYVEPAERYIKDRTLPFHSVIYHEDDINYPHKYGPQGGCADHSVFE
RMRKYQMTGVEEVTQIPQEEHAANGPELLRKKRTTSAEKNTCQLYIQTDHLFFKYYGTRE
AVIAQISSHVKAIDTIYQTTDFSGIRNISFMVKRIRINTTADEKDPTNPFRFPNIGVEKF
LELNSEQNHDDYCLAYVFTDRDFDDGVLGLAWVGAPSGSSGGICEKSKLYSDGKKKSLNT
GIITVQNYGSHVPPKVSHITFAHEVGHNFGSPHDSGTECTPGESKNLGQKENGNYIMYAR
ATSGDKLNNNKFSLCSIRNISQVLEKKRNNCFVESGQPICGNGMVEQGEECDCGYSDQCK
DECCFDANQPEGRKCKLKPGKQCSPSQGPCCTAQCAFKSKSEKCRDDSDCAREGICNGFT
ALCPASDPKPNFTDCNRHTQVCINGQCAGSICEKYGLEECTCASSDGKDDKELCHVCCMK
KMDPSTCASTGSVQWSRHFSGRTITLQPGSPCNDFRGYCDVFMRCRLVDADGPLARLKKA
IFSPELYENIAEWIVAHWWAVLLMGIALIMLMAGFIKICSVHTPSSNPKLPPPKPLPGTL
KRRRPPQPIQQPQRQRPRESYQMGHMRR
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  Blast E-value cutoff:
BDBM50229639
n/a
NameBDBM50229639
Synonyms:(S)-tetrahydrofuran-3-yl 4-(hydroxycarbamoyl)-4-((4-phenyl-5,6-dihydropyridin-1(2H)-ylsulfonyl)methyl)piperidine-1-carboxylate | CHEMBL251820
TypeSmall organic molecule
Emp. Form.C23H31N3O7S
Mol. Mass.493.573
SMILESONC(=O)C1(CS(=O)(=O)N2CCC(=CC2)c2ccccc2)CCN(CC1)C(=O)O[C@H]1CCOC1 |c:12|
Structure
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