Reaction Details |
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Target | Coagulation factor X |
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Ligand | BDBM50231269 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_460575 (CHEMBL926651) |
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Ki | 22.9±n/a nM |
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Citation | Lee, YK; Parks, DJ; Lu, T; Thieu, TV; Markotan, T; Pan, W; McComsey, DF; Milkiewicz, KL; Crysler, CS; Ninan, N; Abad, MC; Giardino, EC; Maryanoff, BE; Damiano, BP; Player, MR 7-fluoroindazoles as potent and selective inhibitors of factor Xa. J Med Chem51:282-97 (2008) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Coagulation factor X |
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Name: | Coagulation factor X |
Synonyms: | Activated coagulation factor X (FXa) | Activated factor Xa heavy chain | Coagulation factor X precursor | Coagulation factor Xa | F10 | FA10_HUMAN | Factor X heavy chain | Factor X light chain | Factor Xa | Stuart factor | Stuart-Prower factor |
Type: | Enzyme |
Mol. Mass.: | 54726.60 |
Organism: | Homo sapiens (Human) |
Description: | n/a |
Residue: | 488 |
Sequence: | MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEE
TCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKN
CELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERR
KRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQE
CKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGE
AVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGI
VSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSG
GPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPE
VITSSPLK
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BDBM50231269 |
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n/a |
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Name | BDBM50231269 |
Synonyms: | 1-{4-[1-(3-aminobenzo[d]isoxazol-5-yl)-7-fluoro-3-trifluoromethyl-1H-indazol-6-yl]-3-fluorophenyl}piperidin-2-one | CHEMBL254621 |
Type | Small organic molecule |
Emp. Form. | C26H18F5N5O2 |
Mol. Mass. | 527.4454 |
SMILES | Nc1noc2ccc(cc12)-n1nc(c2ccc(c(F)c12)-c1ccc(cc1F)N1CCCCC1=O)C(F)(F)F |
Structure |
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