Reaction Details |
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Target | Dihydrofolate reductase |
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Ligand | BDBM50232529 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_461066 (CHEMBL944098) |
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IC50 | 0.39±n/a nM |
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Citation | Thurmond, J; Butchbach, ME; Palomo, M; Pease, B; Rao, M; Bedell, L; Keyvan, M; Pai, G; Mishra, R; Haraldsson, M; Andresson, T; Bragason, G; Thosteinsdottir, M; Bjornsson, JM; Coovert, DD; Burghes, AH; Gurney, ME; Singh, J Synthesis and biological evaluation of novel 2,4-diaminoquinazoline derivatives as SMN2 promoter activators for the potential treatment of spinal muscular atrophy. J Med Chem51:449-69 (2008) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Dihydrofolate reductase |
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Name: | Dihydrofolate reductase |
Synonyms: | DHFR | DYR_HUMAN | Dihydrofolate reductase (DHFR) | Tetrahydrofolate dehydrogenase |
Type: | Enzyme |
Mol. Mass.: | 21453.99 |
Organism: | Homo sapiens (Human) |
Description: | Recombinant human DHFR. |
Residue: | 187 |
Sequence: | MVGSLNCIVAVSQNMGIGKNGDLPWPPLRNEFRYFQRMTTTSSVEGKQNLVIMGKKTWFS
IPEKNRPLKGRINLVLSRELKEPPQGAHFLSRSLDDALKLTEQPELANKVDMVWIVGGSS
VYKEAMNHPGHLKLFVTRIMQDFESDTFFPEIDLEKYKLLPEYPGVLSDVQEEKGIKYKF
EVYEKND
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BDBM50232529 |
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n/a |
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Name | BDBM50232529 |
Synonyms: | 5-(2-fluorobenzyloxy)quinazoline-2,4-diamine | CHEMBL251427 |
Type | Small organic molecule |
Emp. Form. | C15H13FN4O |
Mol. Mass. | 284.2883 |
SMILES | Nc1nc(N)c2c(OCc3ccccc3F)cccc2n1 |
Structure |
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