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TargetDihydrofolate reductase
LigandBDBM50232529
Substrate/Competitorn/a
Meas. Tech.ChEMBL_461066 (CHEMBL944098)
IC50 0.39±n/a nM
Citation Thurmond, JButchbach, MEPalomo, MPease, BRao, MBedell, LKeyvan, MPai, GMishra, RHaraldsson, MAndresson, TBragason, GThosteinsdottir, MBjornsson, JMCoovert, DDBurghes, AHGurney, MESingh, J Synthesis and biological evaluation of novel 2,4-diaminoquinazoline derivatives as SMN2 promoter activators for the potential treatment of spinal muscular atrophy. J Med Chem51:449-69 (2008) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Dihydrofolate reductase
Name:Dihydrofolate reductase
Synonyms:DHFR | DYR_HUMAN | Dihydrofolate reductase (DHFR) | Tetrahydrofolate dehydrogenase
Type:Enzyme
Mol. Mass.:21453.99
Organism:Homo sapiens (Human)
Description:Recombinant human DHFR.
Residue:187
Sequence:
MVGSLNCIVAVSQNMGIGKNGDLPWPPLRNEFRYFQRMTTTSSVEGKQNLVIMGKKTWFS
IPEKNRPLKGRINLVLSRELKEPPQGAHFLSRSLDDALKLTEQPELANKVDMVWIVGGSS
VYKEAMNHPGHLKLFVTRIMQDFESDTFFPEIDLEKYKLLPEYPGVLSDVQEEKGIKYKF
EVYEKND
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BDBM50232529
n/a
NameBDBM50232529
Synonyms:5-(2-fluorobenzyloxy)quinazoline-2,4-diamine | CHEMBL251427
TypeSmall organic molecule
Emp. Form.C15H13FN4O
Mol. Mass.284.2883
SMILESNc1nc(N)c2c(OCc3ccccc3F)cccc2n1
Structure
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