Reaction Details |
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Target | Histone deacetylase 1 |
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Ligand | BDBM50232658 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_462156 (CHEMBL944984) |
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EC50 | 5000±n/a nM |
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Citation | Fréchette, S; Leit, S; Woo, SH; Lapointe, G; Jeannotte, G; Moradei, O; Paquin, I; Bouchain, G; Raeppel, S; Gaudette, F; Zhou, N; Vaisburg, A; Fournel, M; Yan, PT; Trachy-Bourget, MC; Kalita, A; Robert, MF; Lu, A; Rahil, J; Robert Macleod, A; Besterman, JM; Li, Z; Delorme, D 4-(Heteroarylaminomethyl)-N-(2-aminophenyl)-benzamides and their analogs as a novel class of histone deacetylase inhibitors. Bioorg Med Chem Lett18:1502-6 (2008) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Histone deacetylase 1 |
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Name: | Histone deacetylase 1 |
Synonyms: | Cereblon/Histone deacetylase 1 | HD1 | HDAC1 | HDAC1_HUMAN | Histone deacetylase 1 (HDAC1) | Human HDAC1 | RPD3L1 |
Type: | Enzyme |
Mol. Mass.: | 55090.27 |
Organism: | Homo sapiens (Human) |
Description: | Q13547 |
Residue: | 482 |
Sequence: | MAQTQGTRRKVCYYYDGDVGNYYYGQGHPMKPHRIRMTHNLLLNYGLYRKMEIYRPHKAN
AEEMTKYHSDDYIKFLRSIRPDNMSEYSKQMQRFNVGEDCPVFDGLFEFCQLSTGGSVAS
AVKLNKQQTDIAVNWAGGLHHAKKSEASGFCYVNDIVLAILELLKYHQRVLYIDIDIHHG
DGVEEAFYTTDRVMTVSFHKYGEYFPGTGDLRDIGAGKGKYYAVNYPLRDGIDDESYEAI
FKPVMSKVMEMFQPSAVVLQCGSDSLSGDRLGCFNLTIKGHAKCVEFVKSFNLPMLMLGG
GGYTIRNVARCWTYETAVALDTEIPNELPYNDYFEYFGPDFKLHISPSNMTNQNTNEYLE
KIKQRLFENLRMLPHAPGVQMQAIPEDAIPEESGDEDEDDPDKRISICSSDKRIACEEEF
SDSEEEGEGGRKNSSNFKKAKRVKTEDEKEKDPEEKKEVTEEEKTKEEKPEAKGVKEEVK
LA
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BDBM50232658 |
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n/a |
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Name | BDBM50232658 |
Synonyms: | CHEMBL254311 | N-(2-aminophenyl)-4-((6-(2-morpholinoethylamino)benzo[d]thiazol-2-ylthio)methyl)benzamide |
Type | Small organic molecule |
Emp. Form. | C27H29N5O2S2 |
Mol. Mass. | 519.681 |
SMILES | Nc1ccccc1NC(=O)c1ccc(CSc2nc3ccc(NCCN4CCOCC4)cc3s2)cc1 |
Structure |
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