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TargetC-X-C chemokine receptor type 1
LigandBDBM50233574
Substrate/Competitorn/a
Meas. Tech.ChEMBL_462399 (CHEMBL927215)
IC50 62±n/a nM
Citation Yu, YDwyer, MPChao, JAki, CChao, JPurakkattle, BRindgen, DBond, RMayer-Ezel, RJakway, JQiu, HHipkin, RWFossetta, JGonsiorek, WBian, HFan, XTerminelli, CFine, JLundell, DMerritt, JRHe, ZLai, GWu, MTaveras, A Synthesis and structure-activity relationships of heteroaryl substituted-3,4-diamino-3-cyclobut-3-ene-1,2-dione CXCR2/CXCR1 receptor antagonists. Bioorg Med Chem Lett18:1318-22 (2008) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
C-X-C chemokine receptor type 1
Name:C-X-C chemokine receptor type 1
Synonyms:C-X-C chemokine receptor type 1 (CXCR-1) | C-X-C chemokine receptor type 1 (CXCR1) | CMKAR1 | CXCR1 | CXCR1_HUMAN | IL8RA | Interleukin-8 receptor A | Interleukin-8 receptors, CXCR1/CXCR2
Type:Enzyme
Mol. Mass.:39803.83
Organism:Homo sapiens (Human)
Description:P25024
Residue:350
Sequence:
MSNITDPQMWDFDDLNFTGMPPADEDYSPCMLETETLNKYVVIIAYALVFLLSLLGNSLV
MLVILYSRVGRSVTDVYLLNLALADLLFALTLPIWAASKVNGWIFGTFLCKVVSLLKEVN
FYSGILLLACISVDRYLAIVHATRTLTQKRHLVKFVCLGCWGLSMNLSLPFFLFRQAYHP
NNSSPVCYEVLGNDTAKWRMVLRILPHTFGFIVPLFVMLFCYGFTLRTLFKAHMGQKHRA
MRVIFAVVLIFLLCWLPYNLVLLADTLMRTQVIQESCERRNNIGRALDATEILGFLHSCL
NPIIYAFIGQNFRHGFLKILAMHGLVSKEFLARHRVTSYTSSSVNVSSNL
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BDBM50233574
n/a
NameBDBM50233574
Synonyms:(R)-3-(2-(1-(4-chlorofuran-2-yl)propylamino)-3,4-dioxocyclobut-1-enylamino)-2-hydroxy-N,N-dimethylbenzamide | CHEMBL253714
TypeSmall organic molecule
Emp. Form.C20H20ClN3O5
Mol. Mass.417.843
SMILESCC[C@@H](Nc1c(Nc2cccc(C(=O)N(C)C)c2O)c(=O)c1=O)c1cc(Cl)co1
Structure
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