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TargetComplement C1s subcomponent
LigandBDBM50233675
Substrate/Competitorn/a
Meas. Tech.ChEMBL_462407 (CHEMBL927223)
Ki 260±n/a nM
Citation Travins, JMAli, FHuang, HBallentine, SKKhalil, EHufnagel, HRPan, WGushue, JLeonard, KBone, RFSoll, RMDesJarlais, RLCrysler, CSNinan, NKirkpatrick, JCummings, MDHuebert, NMolloy, CJGaul, MTomczuk, BESubasinghe, NL Biphenylsulfonyl-thiophene-carboxamidine inhibitors of the complement component C1s. Bioorg Med Chem Lett18:1603-6 (2008) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Complement C1s subcomponent
Name:Complement C1s subcomponent
Synonyms:C1 esterase | C1S | C1S_HUMAN | Complement C1s | Complement C1s subcomponent | Complement C1s subcomponent heavy chain | Complement C1s subcomponent light chain | Complement component 1 subcomponent s | Trypsin | complement component 1, s subcomponent
Type:Protein
Mol. Mass.:76657.91
Organism:Homo sapiens (Human)
Description:P09871
Residue:688
Sequence:
MWCIVLFSLLAWVYAEPTMYGEILSPNYPQAYPSEVEKSWDIEVPEGYGIHLYFTHLDIE
LSENCAYDSVQIISGDTEEGRLCGQRSSNNPHSPIVEEFQVPYNKLQVIFKSDFSNEERF
TGFAAYYVATDINECTDFVDVPCSHFCNNFIGGYFCSCPPEYFLHDDMKNCGVNCSGDVF
TALIGEIASPNYPKPYPENSRCEYQIRLEKGFQVVVTLRREDFDVEAADSAGNCLDSLVF
VAGDRQFGPYCGHGFPGPLNIETKSNALDIIFQTDLTGQKKGWKLRYHGDPMPCPKEDTP
NSVWEPAKAKYVFRDVVQITCLDGFEVVEGRVGATSFYSTCQSNGKWSNSKLKCQPVDCG
IPESIENGKVEDPESTLFGSVIRYTCEEPYYYMENGGGGEYHCAGNGSWVNEVLGPELPK
CVPVCGVPREPFEEKQRIIGGSDADIKNFPWQVFFDNPWAGGALINEYWVLTAAHVVEGN
REPTMYVGSTSVQTSRLAKSKMLTPEHVFIHPGWKLLEVPEGRTNFDNDIALVRLKDPVK
MGPTVSPICLPGTSSDYNLMDGDLGLISGWGRTEKRDRAVRLKAARLPVAPLRKCKEVKV
EKPTADAEAYVFTPNMICAGGEKGMDSCKGDSGGAFAVQDPNDKTKFYAAGLVSWGPQCG
TYGLYTRVKNYVDWIMKTMQENSTPRED
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM50233675
n/a
NameBDBM50233675
Synonyms:4-(biphenyl-3-sulfonyl)-5-methylsulfanyl-thiophene-2-carboxamidine | CHEMBL252393
TypeSmall organic molecule
Emp. Form.C18H16N2O2S3
Mol. Mass.388.527
SMILESCSc1sc(cc1S(=O)(=O)c1cccc(c1)-c1ccccc1)C(N)=N
Structure
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