Reaction Details |
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Target | Complement C1s subcomponent |
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Ligand | BDBM50233682 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_462407 (CHEMBL927223) |
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Ki | 490±n/a nM |
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Citation | Travins, JM; Ali, F; Huang, H; Ballentine, SK; Khalil, E; Hufnagel, HR; Pan, W; Gushue, J; Leonard, K; Bone, RF; Soll, RM; DesJarlais, RL; Crysler, CS; Ninan, N; Kirkpatrick, J; Cummings, MD; Huebert, N; Molloy, CJ; Gaul, M; Tomczuk, BE; Subasinghe, NL Biphenylsulfonyl-thiophene-carboxamidine inhibitors of the complement component C1s. Bioorg Med Chem Lett18:1603-6 (2008) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Complement C1s subcomponent |
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Name: | Complement C1s subcomponent |
Synonyms: | C1 esterase | C1S | C1S_HUMAN | Complement C1s | Complement C1s subcomponent | Complement C1s subcomponent heavy chain | Complement C1s subcomponent light chain | Complement component 1 subcomponent s | Trypsin | complement component 1, s subcomponent |
Type: | Protein |
Mol. Mass.: | 76657.91 |
Organism: | Homo sapiens (Human) |
Description: | P09871 |
Residue: | 688 |
Sequence: | MWCIVLFSLLAWVYAEPTMYGEILSPNYPQAYPSEVEKSWDIEVPEGYGIHLYFTHLDIE
LSENCAYDSVQIISGDTEEGRLCGQRSSNNPHSPIVEEFQVPYNKLQVIFKSDFSNEERF
TGFAAYYVATDINECTDFVDVPCSHFCNNFIGGYFCSCPPEYFLHDDMKNCGVNCSGDVF
TALIGEIASPNYPKPYPENSRCEYQIRLEKGFQVVVTLRREDFDVEAADSAGNCLDSLVF
VAGDRQFGPYCGHGFPGPLNIETKSNALDIIFQTDLTGQKKGWKLRYHGDPMPCPKEDTP
NSVWEPAKAKYVFRDVVQITCLDGFEVVEGRVGATSFYSTCQSNGKWSNSKLKCQPVDCG
IPESIENGKVEDPESTLFGSVIRYTCEEPYYYMENGGGGEYHCAGNGSWVNEVLGPELPK
CVPVCGVPREPFEEKQRIIGGSDADIKNFPWQVFFDNPWAGGALINEYWVLTAAHVVEGN
REPTMYVGSTSVQTSRLAKSKMLTPEHVFIHPGWKLLEVPEGRTNFDNDIALVRLKDPVK
MGPTVSPICLPGTSSDYNLMDGDLGLISGWGRTEKRDRAVRLKAARLPVAPLRKCKEVKV
EKPTADAEAYVFTPNMICAGGEKGMDSCKGDSGGAFAVQDPNDKTKFYAAGLVSWGPQCG
TYGLYTRVKNYVDWIMKTMQENSTPRED
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BDBM50233682 |
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n/a |
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Name | BDBM50233682 |
Synonyms: | 4-(3-methoxy-biphenyl-3-sulfonyl)-5-methylsulfanyl-thiophene-2-carboxamidine | CHEMBL399262 |
Type | Small organic molecule |
Emp. Form. | C19H18N2O3S3 |
Mol. Mass. | 418.553 |
SMILES | COc1cccc(c1)-c1cccc(c1)S(=O)(=O)c1cc(sc1SC)C(N)=N |
Structure |
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