Reaction Details |
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Target | DNA polymerase beta |
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Ligand | BDBM50241570 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_525612 (CHEMBL972903) |
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Ki | 28000±n/a nM |
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Citation | Deng, JZ; Starck, SR; Sun, DA; Sabat, M; Hecht, SM A new 7,8-euphadien-type triterpenoid from Brackenridgea nitida and Bleasdalea bleasdalei that inhibits DNA polymerase beta. J Nat Prod63:1356-60 (2000) [PubMed] |
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More Info.: | Get all data from this article, Assay Method |
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DNA polymerase beta |
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Name: | DNA polymerase beta |
Synonyms: | DNA Polymerase beta | DPOLB_RAT | Polb |
Type: | PROTEIN |
Mol. Mass.: | 38334.34 |
Organism: | Rattus norvegicus |
Description: | ChEMBL_1361926 |
Residue: | 335 |
Sequence: | MSKRKAPQETLNGGITDMLVELANFEKNVSQAIHKYNAYRKAASVIAKYPHKIKSGAEAK
KLPGVGTKIAEKIDEFLATGKLRKLEKIRQDDTSSSINFLTRVTGIGPSAARKLVDEGIK
TLEDLRKNEDKLNHHQRIGLKYFEDFEKRIPREEMLQMQDIVLNEVKKLDPEYIATVCGS
FRRGAESSGDMDVLLTHPNFTSESSKQPKLLHRVVEQLQKVRFITDTLSKGETKFMGVCQ
LPSENDENEYPHRRIDIRLIPKDQYYCGVLYFTGSDIFNKNMRAHALEKGFTINEYTIRP
LGVTGVAGEPLPVDSEQDIFDYIQWRYREPKDRSE
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BDBM50241570 |
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n/a |
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Name | BDBM50241570 |
Synonyms: | (24E)-3beta-hydroxy-7,24-euphadien-26-oic acid | CHEMBL519411 |
Type | Small organic molecule |
Emp. Form. | C31H50O3 |
Mol. Mass. | 470.7269 |
SMILES | C[C@@H](CC\C=C(/C)C(O)=O)[C@]1(C)CC[C@]2(C)C3=CC[C@H]4C(C)(C)[C@@H](O)CC[C@]4(C)[C@H]3CC[C@@]12C |r,t:16| |
Structure |
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