| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Type II restriction enzyme EcoRI |
|---|
| Ligand | BDBM50242374 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_509275 (CHEMBL996019) |
|---|
| IC50 | >250000±n/a nM |
|---|
| Citation |  Suzuki, K; Yahara, S; Maehata, K; Uyeda, M Isoaurostatin, a novel topoisomerase inhibitor produced by Thermomonospora alba. J Nat Prod64:204-7 (2001) [PubMed] |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Type II restriction enzyme EcoRI |
|---|
| Name: | Type II restriction enzyme EcoRI |
|---|
| Synonyms: | T2E1_ECOLX | Type-2 restriction enzyme EcoRI | ecoRIR |
|---|
| Type: | PROTEIN |
|---|
| Mol. Mass.: | 31063.04 |
|---|
| Organism: | Escherichia coli |
|---|
| Description: | ChEMBL_504581 |
|---|
| Residue: | 277 |
|---|
| Sequence: | MSNKKQSNRLTEQHKLSQGVIGIFGDYAKAHDLAVGEVSKLVKKALSNEYPQLSFRYRDS
IKKTEINEALKKIDPDLGGTLFVSNSSIKPDGGIVEVKDDYGEWRVVLVAEAKHQGKDII
NIRNGLLVGKRGDQDLMAAGNAIERSHKNISEIANFMLSESHFPYVLFLEGSNFLTENIS
ITRPDGRVVNLEYNSGILNRLDRLTAANYGMPINSNLCINKFVNHKDKSIMLQAASIYTQ
GDGREWDSKIMFEIMFDISTTSLRVLGRDLFEQLTSK
|
|
|
|---|
| BDBM50242374 |
|---|
| n/a |
|---|
| Name | BDBM50242374 |
|---|
| Synonyms: | CHEMBL505529 | topostatin |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C36H58N4O11S |
|---|
| Mol. Mass. | 754.931 |
|---|
| SMILES | CCCCCCCC(C)CC=C(C)C=CC(=O)C(C)CCC1OC(=O)[C@H](CC(OS(O)(=O)=O)C(N)=O)NC(=O)[C@@H](C)CNC(=O)C(=C)NC(=O)C1C |r,w:14.14,10.9| |
|---|
| Structure | 
|
|---|
Search and Browse
