Reaction Details | |||
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Target | DNA topoisomerase 1 | ||
Ligand | BDBM50008923 | ||
Substrate/Competitor | n/a | ||
Meas. Tech. | ChEMBL_509265 (CHEMBL996009) | ||
IC50 | 9000±n/a nM | ||
Citation | Suzuki, K; Yahara, S; Maehata, K; Uyeda, M Isoaurostatin, a novel topoisomerase inhibitor produced by Thermomonospora alba. J Nat Prod64:204-7 (2001) [PubMed] | ||
More Info.: | Get all data from this article, Assay Method | ||
DNA topoisomerase 1 | |||
Name: | DNA topoisomerase 1 | ||
Synonyms: | DNA topoisomerase I | DNA topoisomerase I (Topo I) | TOP1 | TOP1_HUMAN | ||
Type: | Enzyme | ||
Mol. Mass.: | 90771.02 | ||
Organism: | Homo sapiens (Human) | ||
Description: | P11387 | ||
Residue: | 765 | ||
Sequence: |
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BDBM50008923 | |||
n/a | |||
Name | BDBM50008923 | ||
Synonyms: | (S)-4-ethyl-4-hydroxy-1,12-dihydro-4H-2-oxa-6,12a-diaza-dibenzo[b,h]florene-3,13-dione | (S)-4-ethyl-4-hydroxy-1,12-dihydro-4H-2-oxa-6,12a-diaza-dibenzo[b,h]fluorene-3,13-dione | 4-Ethyl-4-hydroxy-1,12-dihydro-4H-2-oxa-6,12a-diaza-dibenzo[b,h]fluorene-3,13-dione | 4-Ethyl-4-hydroxy-1,12-dihydro-4H-2-oxa-6,12a-diaza-dibenzo[b,h]fluorene-3,13-dione (CPT, Camptothecin) | 4-Ethyl-4-hydroxy-1,12-dihydro-4H-2-oxa-6,12a-diaza-dibenzo[b,h]fluorene-3,13-dione (Camptothecin) | 4-Ethyl-4-hydroxy-1,12-dihydro-4H-2-oxa-6,12a-diaza-dibenzo[b,h]fluorene-3,13-dione (camptothecin or CPT) | 4-ethyl-4-hydroxy-(4S)-3,4,12,14-tetrahydro-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14-dione | CHEMBL65 | Camptothecin (CT) | camptothecine | cid_24360 | ||
Type | Small organic molecule | ||
Emp. Form. | C20H16N2O4 | ||
Mol. Mass. | 348.352 | ||
SMILES | CC[C@@]1(O)C(=O)OCc2c1cc1-c3nc4ccccc4cc3Cn1c2=O |r| | ||
Structure |