Ki Summary

Reaction Details

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Target

Type II restriction enzyme BamHI

Ligand

BDBM50008923

Substrate/Competitor

n/a

Meas. Tech.

ChEMBL_509274 (CHEMBL996018)

IC50

>300000±n/a nM

Citation

Suzuki, K; Yahara, S; Maehata, K; Uyeda, M Isoaurostatin, a novel topoisomerase inhibitor produced by Thermomonospora alba. J Nat Prod64:204-7 (2001) [PubMed]

More Info.:

Get all data from this article, Assay Method

Type II restriction enzyme BamHI

Name:

Type II restriction enzyme BamHI

Synonyms:

T2BA_BACAM | Type-2 restriction enzyme BamHI | bamHIR

Type:

PROTEIN

Mol. Mass.:

24567.99

Organism:

Bacillus amyloliquefaciens

Description:

ChEMBL_509274

Residue:

213

Sequence:

MEVEKEFITDEAKELLSKDKLIQQAYNEVKTSICSPIWPATSKTFTINNTEKNCNGVVPI
KELCYTLLEDTYNWYREKPLDILKLEKKKGGPIDVYKEFIENSELKRVGMEFETGNISSA
HRSMNKLLLGLKHGEIDLAIILMPIKQLAYYLTDRVTNFEELEPYFELTEGQPFIFIGFN
AEAYNSNVPLIPKGSDGMSKRSIKKWKDKVENK

BDBM50008923

n/a

Name

BDBM50008923

Synonyms:

(S)-4-ethyl-4-hydroxy-1,12-dihydro-4H-2-oxa-6,12a-diaza-dibenzo[b,h]florene-3,13-dione | (S)-4-ethyl-4-hydroxy-1,12-dihydro-4H-2-oxa-6,12a-diaza-dibenzo[b,h]fluorene-3,13-dione | 4-Ethyl-4-hydroxy-1,12-dihydro-4H-2-oxa-6,12a-diaza-dibenzo[b,h]fluorene-3,13-dione | 4-Ethyl-4-hydroxy-1,12-dihydro-4H-2-oxa-6,12a-diaza-dibenzo[b,h]fluorene-3,13-dione (CPT, Camptothecin) | 4-Ethyl-4-hydroxy-1,12-dihydro-4H-2-oxa-6,12a-diaza-dibenzo[b,h]fluorene-3,13-dione (Camptothecin) | 4-Ethyl-4-hydroxy-1,12-dihydro-4H-2-oxa-6,12a-diaza-dibenzo[b,h]fluorene-3,13-dione (camptothecin or CPT) | 4-ethyl-4-hydroxy-(4S)-3,4,12,14-tetrahydro-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14-dione | CHEMBL65 | Camptothecin (CT) | camptothecine | cid_24360

Type

Small organic molecule

Emp. Form.

C20H16N2O4

Mol. Mass.

348.352

SMILES

CC[C@@]1(O)C(=O)OCc2c1cc1-c3nc4ccccc4cc3Cn1c2=O |r|

Structure