Reaction Details |
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Target | DNA topoisomerase 1 |
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Ligand | BDBM22984 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_509262 (CHEMBL996006) |
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IC50 | >200000±n/a nM |
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Citation | Suzuki, K; Yahara, S; Maehata, K; Uyeda, M Isoaurostatin, a novel topoisomerase inhibitor produced by Thermomonospora alba. J Nat Prod64:204-7 (2001) [PubMed] |
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More Info.: | Get all data from this article, Assay Method |
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DNA topoisomerase 1 |
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Name: | DNA topoisomerase 1 |
Synonyms: | TOP1 | TOP1_CHLAE |
Type: | PROTEIN |
Mol. Mass.: | 90999.27 |
Organism: | Cercopithecus aethiops |
Description: | ChEMBL_509262 |
Residue: | 767 |
Sequence: | MSGDHLHNDSQIEADFRLNDSHKHKDKHKDREHRHKEHKKDKEKDREKSKHSNSEHKDSE
KKHKEKEKTKHKDGSSEKHKDKHKDRDKEKRKEEKVRASGDAKIKKEKENGFSSPPQIKD
EPEDDGYFVPPKEDIKPLKRPRDEDDADYKPKKIKTEDIKKEKKRKLEEEEDGKLRKPKN
KDKDKKVPEPDNKKKKPKKEEEQKWKWWEEERYPEGIKWKFLEHKGPVFAPPYEPLPDSV
KFYYDGKVMKLSPKAEEVATFFAKMLDHEYTTKEIFRKNFFKDWRKEMTNEEKNIITNLS
KCDFTQMSQYFKAQTEARKQMSKEEKLKIKEENEKLLKEYGFCIMDNHKERIANFKIEPP
GLFRGRGNHPKMGMLKRRIMPEDIIINCSKDAKVPSPPPGHKWKEVRHDNKVTWLVSWTE
NIQGSIKYIMLNPSSRIKGEKDWQKYETARRLKKCVDKIRNQYREDWKSKEMKVRQRAVA
LYFIDKLALRAGNEKEEGETADTVGCCSLRVEHINLHPELDGQEYVVEFDFLGKDSIRYY
NKVPVEKRVFKNLQLFMENKQPEDDLFDRLNTGILNKHLQDLMEGLTAKVFRTYNASITL
QQQLKELTAPDENIPAKILSYNRANRAVAILCNHQRAPPKTFEKSMMNLQSKIDAKKEQL
ADARRDLKSAKADAKVMKDAKTKKVVESKKKAVQRLEEQLMKLEVQATDREENKQIALGT
SKLNYLDPRITVAWCKKWGVPIEKIYNKTQREKFAWAIDMADEDYEF
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BDBM22984 |
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n/a |
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Name | BDBM22984 |
Synonyms: | (8S,10S)-10-{[(2R,4S,5S,6S)-4-amino-5-hydroxy-6-methyloxan-2-yl]oxy}-6,8,11-trihydroxy-8-(2-hydroxyacetyl)-1-methoxy-5,7,8,9,10,12-hexahydrotetracene-5,12-dione | Adriamycin | Adriblastina | CHEMBL53463 | Doxil | Doxorubicin |
Type | Antibiotic |
Emp. Form. | C27H29NO11 |
Mol. Mass. | 543.5193 |
SMILES | COc1cccc2C(=O)c3c(O)c4C[C@](O)(C[C@H](O[C@H]5C[C@H](N)[C@H](O)[C@H](C)O5)c4c(O)c3C(=O)c12)C(=O)CO |r| |
Structure |
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