| Reaction Details |
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 | Report a problem with these data |
| Target | DNA topoisomerase 1 |
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| Ligand | BDBM50250904 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_509474 (CHEMBL1008110) |
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| IC50 | >1000000±n/a nM |
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| Citation |  Carballeira, NM; Betancourt, JE; Orellano, EA; González, FA Total synthesis and biological evaluation of (5Z,9Z)-5,9-hexadecadienoic acid, an inhibitor of human topoisomerase I. J Nat Prod65:1715-8 (2002) [PubMed] |
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| More Info.: | Get all data from this article, Assay Method |
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| DNA topoisomerase 1 |
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| Name: | DNA topoisomerase 1 |
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| Synonyms: | DNA topoisomerase I | DNA topoisomerase I (Topo I) | TOP1 | TOP1_HUMAN |
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| Type: | Enzyme |
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| Mol. Mass.: | 90771.02 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P11387 |
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| Residue: | 765 |
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| Sequence: | MSGDHLHNDSQIEADFRLNDSHKHKDKHKDREHRHKEHKKEKDREKSKHSNSEHKDSEKK
HKEKEKTKHKDGSSEKHKDKHKDRDKEKRKEEKVRASGDAKIKKEKENGFSSPPQIKDEP
EDDGYFVPPKEDIKPLKRPRDEDDADYKPKKIKTEDTKKEKKRKLEEEEDGKLKKPKNKD
KDKKVPEPDNKKKKPKKEEEQKWKWWEEERYPEGIKWKFLEHKGPVFAPPYEPLPENVKF
YYDGKVMKLSPKAEEVATFFAKMLDHEYTTKEIFRKNFFKDWRKEMTNEEKNIITNLSKC
DFTQMSQYFKAQTEARKQMSKEEKLKIKEENEKLLKEYGFCIMDNHKERIANFKIEPPGL
FRGRGNHPKMGMLKRRIMPEDIIINCSKDAKVPSPPPGHKWKEVRHDNKVTWLVSWTENI
QGSIKYIMLNPSSRIKGEKDWQKYETARRLKKCVDKIRNQYREDWKSKEMKVRQRAVALY
FIDKLALRAGNEKEEGETADTVGCCSLRVEHINLHPELDGQEYVVEFDFLGKDSIRYYNK
VPVEKRVFKNLQLFMENKQPEDDLFDRLNTGILNKHLQDLMEGLTAKVFRTYNASITLQQ
QLKELTAPDENIPAKILSYNRANRAVAILCNHQRAPPKTFEKSMMNLQTKIDAKKEQLAD
ARRDLKSAKADAKVMKDAKTKKVVESKKKAVQRLEEQLMKLEVQATDREENKQIALGTSK
LNYLDPRITVAWCKKWGVPIEKIYNKTQREKFAWAIDMADEDYEF
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| BDBM50250904 |
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| n/a |
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| Name | BDBM50250904 |
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| Synonyms: | CHEMBL460657 | Elaidinsaeure | elaidic acid | trans-Delta(9)-octadecenoic acid |
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| Type | Small organic molecule |
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| Emp. Form. | C18H34O2 |
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| Mol. Mass. | 282.4614 |
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| SMILES | CCCCCCCC\C=C\CCCCCCCC(O)=O |
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| Structure | 
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