| Reaction Details |
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 | Report a problem with these data |
| Target | DNA polymerase beta |
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| Ligand | BDBM50242088 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_550598 (CHEMBL999199) |
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| IC50 | 15300±n/a nM |
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| Citation |  Prakash Chaturvedula, VS; Hecht, SM; Gao, Z; Jones, SH; Feng, X; Kingston, DG New neolignans that inhibit DNA polymerase beta lyase. J Nat Prod67:964-7 (2004) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| DNA polymerase beta |
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| Name: | DNA polymerase beta |
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| Synonyms: | DNA polymerase beta (Pol β) | DPOLB_HUMAN | POLB |
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| Type: | Protein |
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| Mol. Mass.: | 38188.76 |
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| Organism: | Homo sapiens (Human) |
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| Description: | n/a |
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| Residue: | 335 |
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| Sequence: | MSKRKAPQETLNGGITDMLTELANFEKNVSQAIHKYNAYRKAASVIAKYPHKIKSGAEAK
KLPGVGTKIAEKIDEFLATGKLRKLEKIRQDDTSSSINFLTRVSGIGPSAARKFVDEGIK
TLEDLRKNEDKLNHHQRIGLKYFGDFEKRIPREEMLQMQDIVLNEVKKVDSEYIATVCGS
FRRGAESSGDMDVLLTHPSFTSESTKQPKLLHQVVEQLQKVHFITDTLSKGETKFMGVCQ
LPSKNDEKEYPHRRIDIRLIPKDQYYCGVLYFTGSDIFNKNMRAHALEKGFTINEYTIRP
LGVTGVAGEPLPVDSEKDIFDYIQWKYREPKDRSE
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| BDBM50242088 |
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| n/a |
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| Name | BDBM50242088 |
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| Synonyms: | (7S,8R,1'S,5'S,6'R)-delta 2',8'-5',6'-Dihydroxy-3'-methoxy-3,4-methylenedioxy-4'-oxo-8.1',7.5'-neolignan | CHEMBL511272 |
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| Type | Small organic molecule |
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| Emp. Form. | C20H22O6 |
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| Mol. Mass. | 358.3851 |
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| SMILES | COC1=C[C@]2(CC=C)[C@H](C)[C@@H](c3ccc4OCOc4c3)[C@](O)([C@@H]2O)C1=O |r,t:2,TLB:23:22:10.8:3.24.2| |
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| Structure | 
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