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TargetLysine--tRNA ligase
LigandBDBM482158
Substrate/Competitorn/a
Meas. Tech.ChEMBL_509006 (CHEMBL1006347)
IC50 1474±n/a nM
Citation Galkin, AVMelnick, JSKim, SHood, TLLi, NLi, LXia, GSteensma, RChopiuk, GJiang, JWan, YDing, PLiu, YSun, FSchultz, PGGray, NSWarmuth, M Identification of NVP-TAE684, a potent, selective, and efficacious inhibitor of NPM-ALK. Proc Natl Acad Sci U S A104:270-5 (2007) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Lysine--tRNA ligase
Name:Lysine--tRNA ligase
Synonyms:KARS | KARS1 | KIAA0070 | Lysyl-tRNA synthetase | SYK_HUMAN
Type:PROTEIN
Mol. Mass.:68044.78
Organism:Homo sapiens (Human)
Description:ChEMBL_960665
Residue:597
Sequence:
MAAVQAAEVKVDGSEPKLSKNELKRRLKAEKKVAEKEAKQKELSEKQLSQATAAATNHTT
DNGVGPEEESVDPNQYYKIRSQAIHQLKVNGEDPYPHKFHVDISLTDFIQKYSHLQPGDH
LTDITLKVAGRIHAKRASGGKLIFYDLRGEGVKLQVMANSRNYKSEEEFIHINNKLRRGD
IIGVQGNPGKTKKGELSIIPYEITLLSPCLHMLPHLHFGLKDKETRYRQRYLDLILNDFV
RQKFIIRSKIITYIRSFLDELGFLEIETPMMNIIPGGAVAKPFITYHNELDMNLYMRIAP
ELYHKMLVVGGIDRVYEIGRQFRNEGIDLTHNPEFTTCEFYMAYADYHDLMEITEKMVSG
MVKHITGSYKVTYHPDGPEGQAYDVDFTPPFRRINMVEELEKALGMKLPETNLFETEETR
KILDDICVAKAVECPPPRTTARLLDKLVGEFLEVTCINPTFICDHPQIMSPLAKWHRSKE
GLTERFELFVMKKEICNAYTELNDPMRQRQLFEEQAKAKAAGDDEAMFIDENFCTALEYG
LPPTAGWGMGIDRVAMFLTDSNNIKEVLLFPAMKPEDKKENVATTDTLESTTVGTSV
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM482158
n/a
NameBDBM482158
Synonyms:BDBM50242742 | TAE684
Typen/a
Emp. Form.C30H40ClN7O3S
Mol. Mass.614.202
SMILESCOc1cc(ccc1Nc1ncc(Cl)c(Nc2ccccc2S(=O)(=O)C(C)C)n1)N1CCC(CC1)N1CCN(C)CC1
Structure
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