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TargetCyclin-dependent kinase 7
LigandBDBM50269948
Substrate/Competitorn/a
Meas. Tech.ChEMBL_505238 (CHEMBL941345)
IC50 197±n/a nM
Citation Slack-Davis, JKMartin, KHTilghman, RWIwanicki, MUng, EJAutry, CLuzzio, MJCooper, BKath, JCRoberts, WGParsons, JT Cellular characterization of a novel focal adhesion kinase inhibitor. J Biol Chem282:14845-52 (2007) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Cyclin-dependent kinase 7
Name:Cyclin-dependent kinase 7
Synonyms:39 kDa protein kinase | CAK | CAK1 | CDK-activating kinase | CDK-activating kinase 1 (CAK) | CDK7 | CDK7_HUMAN | CDKN7 | Cell division protein kinase 7 | Cyclin-Dependent Kinase 7 (CDK7) | Cyclin-dependent kinase 7 (CDK7/cyclin H) | MO15 | P39 Mo15 | STK1 | TFIIH basal transcription factor complex kinase subunit
Type:Enzyme Subunit
Mol. Mass.:39047.01
Organism:Homo sapiens (Human)
Description:n/a
Residue:346
Sequence:
MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTAL
REIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLM
TLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRA
PELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDM
CSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPG
PTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF
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  Blast E-value cutoff:
BDBM50269948
n/a
NameBDBM50269948
Synonyms:6-(4-(3-(methylsulfonyl)benzylamino)-5-(trifluoromethyl)pyrimidin-2-ylamino)-3,4-dihydroquinolin-2(1H)-one | CHEMBL514554 | D3RKN_2 | PF-228 | US10266549, Example 32 | US10774092, Example 32
TypeSmall organic molecule
Emp. Form.C22H20F3N5O3S
Mol. Mass.491.486
SMILESCS(=O)(=O)c1cccc(CNc2nc(Nc3ccc4NC(=O)CCc4c3)ncc2C(F)(F)F)c1
Structure
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