| Reaction Details |
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 | Report a problem with these data |
| Target | Dihydrofolate reductase |
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| Ligand | BDBM50251155 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_530829 (CHEMBL969384) |
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| Ki | 1800±n/a nM |
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| Citation |  Corona, P; Loriga, M; Costi, MP; Ferrari, S; Paglietti, G Synthesis of N-(5,7-diamino-3-phenyl-quinoxalin-2-yl)-3,4,5-substituted anilines and N-[4[(5,7-diamino-3-phenylquinoxalin-2-yl)amino]benzoyl]-l-glutamic acid diethyl ester: evaluation of in vitro anti-cancer and anti-folate activities. Eur J Med Chem43:189-203 (2008) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Dihydrofolate reductase |
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| Name: | Dihydrofolate reductase |
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| Synonyms: | DHFR | DYR_HUMAN | Dihydrofolate reductase (DHFR) | Tetrahydrofolate dehydrogenase |
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| Type: | Enzyme |
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| Mol. Mass.: | 21453.99 |
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| Organism: | Homo sapiens (Human) |
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| Description: | Recombinant human DHFR. |
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| Residue: | 187 |
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| Sequence: | MVGSLNCIVAVSQNMGIGKNGDLPWPPLRNEFRYFQRMTTTSSVEGKQNLVIMGKKTWFS
IPEKNRPLKGRINLVLSRELKEPPQGAHFLSRSLDDALKLTEQPELANKVDMVWIVGGSS
VYKEAMNHPGHLKLFVTRIMQDFESDTFFPEIDLEKYKLLPEYPGVLSDVQEEKGIKYKF
EVYEKND
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| BDBM50251155 |
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| n/a |
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| Name | BDBM50251155 |
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| Synonyms: | 2-[(4-Methoy-phenyl)amino]-3-phenyl-5,7-diaminoquinoxaline | CHEMBL518405 |
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| Type | Small organic molecule |
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| Emp. Form. | C21H19N5O |
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| Mol. Mass. | 357.4085 |
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| SMILES | COc1ccc(Nc2nc3cc(N)cc(N)c3nc2-c2ccccc2)cc1 |
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| Structure | 
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