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TargetDihydrofolate reductase
LigandBDBM50251158
Substrate/Competitorn/a
Meas. Tech.ChEMBL_530829
Ki 100±n/a nM
Citation Corona PLoriga MCosti MPFerrari SPaglietti G Synthesis of N-(5,7-diamino-3-phenyl-quinoxalin-2-yl)-3,4,5-substituted anilines and N-[4[(5,7-diamino-3-phenylquinoxalin-2-yl)amino]benzoyl]-l-glutamic acid diethyl ester: evaluation of in vitro anti-cancer and anti-folate activities. Eur J Med Chem 43:189-203 (2008) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Dihydrofolate reductase
Name:Dihydrofolate reductase
Synonyms:Dihydrofolate reductase (DHFR) | Tetrahydrofolate dehydrogenase
Type:Enzyme
Mol. Mass.:21453.99
Organism:Homo sapiens (Human)
Description:Recombinant human DHFR.
Residue:187
Sequence:
MVGSLNCIVAVSQNMGIGKNGDLPWPPLRNEFRYFQRMTTTSSVEGKQNLVIMGKKTWFS
IPEKNRPLKGRINLVLSRELKEPPQGAHFLSRSLDDALKLTEQPELANKVDMVWIVGGSS
VYKEAMNHPGHLKLFVTRIMQDFESDTFFPEIDLEKYKLLPEYPGVLSDVQEEKGIKYKF
EVYEKND
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BDBM50251158
n/a
NameBDBM50251158
Synonyms:2-[(3,4,5-Trimethoxy-phenyl)amino]-3-phenyl-5,7-diamino-quinoxaline | CHEMBL464504
TypeSmall organic molecule
Emp. Form.C23H23N5O3
Mol. Mass.417.4604
SMILESCOc1cc(Nc2nc3cc(N)cc(N)c3nc2-c2ccccc2)cc(OC)c1OC
Structure
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