| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Histone deacetylase |
|---|
| Ligand | BDBM50242717 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_532345 (CHEMBL973268) |
|---|
| IC50 | 807±n/a nM |
|---|
| Citation |  Ragno, R; Simeoni, S; Rotili, D; Caroli, A; Botta, G; Brosch, G; Massa, S; Mai, A Class II-selective histone deacetylase inhibitors. Part 2: alignment-independent GRIND 3-D QSAR, homology and docking studies. Eur J Med Chem43:621-32 (2008) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Histone deacetylase |
|---|
| Name: | Histone deacetylase |
|---|
| Synonyms: | Histone deacetylase HD1B |
|---|
| Type: | PROTEIN |
|---|
| Mol. Mass.: | 50930.01 |
|---|
| Organism: | Zea mays |
|---|
| Description: | ChEMBL_422128 |
|---|
| Residue: | 458 |
|---|
| Sequence: | MAASGEGVSLPSPAGGEDAHRRRVSYFYEPSIGDYYYGQGHPMKPHRIRMAHSLVVHYGL
HRLLELSRPYPASEADIRRFHSDDYVAFLASATGNPGVLDPRAIKRFNVGEDCPVFDGLF
PFCQASAGGSIGAAVKLNRGDADITVNWAGGLHHAKKSEASGFCYVNDIVLAILELLKFH
RRVLYVDIDVHHGDGVEEAFFTTNRVMTVSFHKYGDFFPGTGHITDVGAAEGKHYALNVP
LSDGIDDTTFRGLFQCIIKKVMEVYQPDVVVLQCGADSLAGDRLGCFNLSVKGHADCLRF
LRSYNVPMMVLGGGGYTIRNVARCWCYETAVAVGVEPDNKLPYNDYYEYFGPDYTLHIQP
KSVENLNTTKDLENIKNMILENLSKIEHVPSTQFHDRPSDPEAPEEKEEDMDKRPPQRSR
LWSGGAYDSDTEDPDSLKSEGKDVTANFQMKDEPKDDL
|
|
|
|---|
| BDBM50242717 |
|---|
| n/a |
|---|
| Name | BDBM50242717 |
|---|
| Synonyms: | (E)-3-(4-((E)-3-(2,6-difluorophenyl)-3-oxoprop-1-enyl)-1-methyl-1H-pyrrol-2-yl)-N-hydroxyacrylamide | CHEMBL461492 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C17H14F2N2O3 |
|---|
| Mol. Mass. | 332.3015 |
|---|
| SMILES | Cn1cc(\C=C\C(=O)c2c(F)cccc2F)cc1\C=C\C(=O)NO |
|---|
| Structure | 
|
|---|
Search and Browse
