| Reaction Details |
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 | Report a problem with these data |
| Target | Squalene synthase |
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| Ligand | BDBM50269936 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_520603 (CHEMBL959525) |
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| IC50 | >1000±n/a nM |
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| Citation |  Cammerer, SB; Jimenez, C; Jones, S; Gros, L; Lorente, SO; Rodrigues, C; Rodrigues, JC; Caldera, A; Ruiz Perez, LM; da Souza, W; Kaiser, M; Brun, R; Urbina, JA; Gonzalez Pacanowska, D; Gilbert, IH Quinuclidine derivatives as potential antiparasitics. Antimicrob Agents Chemother51:4049-61 (2007) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Squalene synthase |
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| Name: | Squalene synthase |
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| Synonyms: | Farnesyltransferase, putative |
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| Type: | PROTEIN |
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| Mol. Mass.: | 47117.40 |
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| Organism: | Leishmania major |
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| Description: | ChEMBL_520603 |
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| Residue: | 414 |
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| Sequence: | MGFFSDSVAMMRVKWQMRSVKIQVPPEETDLRFCYDIMNDVSRSFAVVVAQLADQQLRDA
ICIFYLVLRALDTLEDDMSVPVDVKLKELPKFHTHTSDMSWCMSGVGEGRERELLAKYPC
VSREFKKLKKEYQDVIANICERMANGMCEFLKRPVVTKDDYNQYCHYVAGLVGHGLTQLF
ARCGFEDPSLDDDLTSSNHMGLFLQKTNIIRDYYEDIREEPPRMFWPKEIWGTYVTELKE
LKSESNNAAAVQCLNAMVADALVHVPYIVDYLSALRDPSVFRFCAIPQVMAIATLKEVYN
NPDTFQVKVKVSRPESCRIMLKATTLYSSLSMFRDYCVELQEKLDMQDASSVSIANSLAA
AIERIDLQLKKCQDVSYTRSLLARYPGLGGQFLLTVMDTVAGFFGGRKEIAGHA
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| BDBM50269936 |
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| n/a |
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| Name | BDBM50269936 |
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| Synonyms: | (2S,5S)-2-Hydroxymethyl-5-[1'-2'-(4''-ethoxycarbonylphenyl)}-ethynyl]-1-aza-bicyclo-[2.2.2]-octane | CHEMBL477327 |
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| Type | Small organic molecule |
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| Emp. Form. | C20H25NO3 |
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| Mol. Mass. | 327.4174 |
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| SMILES | CCOC(=O)Cc1ccc(cc1)C#C[C@H]1CN2CCC1C[C@H]2CO |r| |
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| Structure | 
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