| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Squalene synthase |
|---|
| Ligand | BDBM50269940 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_520603 (CHEMBL959525) |
|---|
| IC50 | >1000±n/a nM |
|---|
| Citation |  Cammerer, SB; Jimenez, C; Jones, S; Gros, L; Lorente, SO; Rodrigues, C; Rodrigues, JC; Caldera, A; Ruiz Perez, LM; da Souza, W; Kaiser, M; Brun, R; Urbina, JA; Gonzalez Pacanowska, D; Gilbert, IH Quinuclidine derivatives as potential antiparasitics. Antimicrob Agents Chemother51:4049-61 (2007) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Squalene synthase |
|---|
| Name: | Squalene synthase |
|---|
| Synonyms: | Farnesyltransferase, putative |
|---|
| Type: | PROTEIN |
|---|
| Mol. Mass.: | 47117.40 |
|---|
| Organism: | Leishmania major |
|---|
| Description: | ChEMBL_520603 |
|---|
| Residue: | 414 |
|---|
| Sequence: | MGFFSDSVAMMRVKWQMRSVKIQVPPEETDLRFCYDIMNDVSRSFAVVVAQLADQQLRDA
ICIFYLVLRALDTLEDDMSVPVDVKLKELPKFHTHTSDMSWCMSGVGEGRERELLAKYPC
VSREFKKLKKEYQDVIANICERMANGMCEFLKRPVVTKDDYNQYCHYVAGLVGHGLTQLF
ARCGFEDPSLDDDLTSSNHMGLFLQKTNIIRDYYEDIREEPPRMFWPKEIWGTYVTELKE
LKSESNNAAAVQCLNAMVADALVHVPYIVDYLSALRDPSVFRFCAIPQVMAIATLKEVYN
NPDTFQVKVKVSRPESCRIMLKATTLYSSLSMFRDYCVELQEKLDMQDASSVSIANSLAA
AIERIDLQLKKCQDVSYTRSLLARYPGLGGQFLLTVMDTVAGFFGGRKEIAGHA
|
|
|
|---|
| BDBM50269940 |
|---|
| n/a |
|---|
| Name | BDBM50269940 |
|---|
| Synonyms: | (2S,5S)-2-Hydroxymethyl-5-[1'-(2'-phenyl)-ethynyl]-1-aza-bicyclo-[2.2.2]-octane | CHEMBL391926 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C16H19NO |
|---|
| Mol. Mass. | 241.3282 |
|---|
| SMILES | OC[C@@H]1CC2CCN1C[C@@H]2C#Cc1ccccc1 |r| |
|---|
| Structure | 
|
|---|
Search and Browse
