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TargetSqualene synthase
LigandBDBM50269925
Substrate/Competitorn/a
Meas. Tech.ChEMBL_520603 (CHEMBL959525)
IC50>1000±n/a nM
Citation Cammerer, SBJimenez, CJones, SGros, LLorente, SORodrigues, CRodrigues, JCCaldera, ARuiz Perez, LMda Souza, WKaiser, MBrun, RUrbina, JAGonzalez Pacanowska, DGilbert, IH Quinuclidine derivatives as potential antiparasitics. Antimicrob Agents Chemother51:4049-61 (2007) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Squalene synthase
Name:Squalene synthase
Synonyms:Farnesyltransferase, putative
Type:PROTEIN
Mol. Mass.:47117.40
Organism:Leishmania major
Description:ChEMBL_520603
Residue:414
Sequence:
MGFFSDSVAMMRVKWQMRSVKIQVPPEETDLRFCYDIMNDVSRSFAVVVAQLADQQLRDA
ICIFYLVLRALDTLEDDMSVPVDVKLKELPKFHTHTSDMSWCMSGVGEGRERELLAKYPC
VSREFKKLKKEYQDVIANICERMANGMCEFLKRPVVTKDDYNQYCHYVAGLVGHGLTQLF
ARCGFEDPSLDDDLTSSNHMGLFLQKTNIIRDYYEDIREEPPRMFWPKEIWGTYVTELKE
LKSESNNAAAVQCLNAMVADALVHVPYIVDYLSALRDPSVFRFCAIPQVMAIATLKEVYN
NPDTFQVKVKVSRPESCRIMLKATTLYSSLSMFRDYCVELQEKLDMQDASSVSIANSLAA
AIERIDLQLKKCQDVSYTRSLLARYPGLGGQFLLTVMDTVAGFFGGRKEIAGHA
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM50269925
n/a
NameBDBM50269925
Synonyms:3-[1'-{2'-(2''-Amino-5''-methyl methanoatephenyl)}-ethynyl]-3-quinuclidinol | CHEMBL478531
TypeSmall organic molecule
Emp. Form.C17H20N2O3
Mol. Mass.300.3523
SMILESCOC(=O)c1ccc(N)c(c1)C#CC1(O)CN2CCC1CC2 |(13.38,-19.11,;12.04,-18.35,;10.71,-19.14,;9.37,-18.38,;10.73,-20.68,;12.08,-21.43,;12.09,-22.97,;10.76,-23.75,;10.77,-25.29,;9.43,-22.99,;9.41,-21.46,;8.1,-23.76,;6.78,-24.55,;5.45,-25.32,;5.43,-23.78,;5.45,-26.87,;4.11,-27.64,;2.77,-26.87,;2.77,-25.32,;4.11,-24.54,;3.37,-25.9,;4.86,-26.31,)|
Structure
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