Reaction Details | |||
---|---|---|---|
Report a problem with these data | |||
Target | Squalene synthase | ||
Ligand | BDBM50269925 | ||
Substrate/Competitor | n/a | ||
Meas. Tech. | ChEMBL_520603 (CHEMBL959525) | ||
IC50 | >1000±n/a nM | ||
Citation | Cammerer, SB; Jimenez, C; Jones, S; Gros, L; Lorente, SO; Rodrigues, C; Rodrigues, JC; Caldera, A; Ruiz Perez, LM; da Souza, W; Kaiser, M; Brun, R; Urbina, JA; Gonzalez Pacanowska, D; Gilbert, IH Quinuclidine derivatives as potential antiparasitics. Antimicrob Agents Chemother51:4049-61 (2007) [PubMed] Article | ||
More Info.: | Get all data from this article, Assay Method | ||
Squalene synthase | |||
Name: | Squalene synthase | ||
Synonyms: | Farnesyltransferase, putative | ||
Type: | PROTEIN | ||
Mol. Mass.: | 47117.40 | ||
Organism: | Leishmania major | ||
Description: | ChEMBL_520603 | ||
Residue: | 414 | ||
Sequence: |
| ||
BDBM50269925 | |||
n/a | |||
Name | BDBM50269925 | ||
Synonyms: | 3-[1'-{2'-(2''-Amino-5''-methyl methanoatephenyl)}-ethynyl]-3-quinuclidinol | CHEMBL478531 | ||
Type | Small organic molecule | ||
Emp. Form. | C17H20N2O3 | ||
Mol. Mass. | 300.3523 | ||
SMILES | COC(=O)c1ccc(N)c(c1)C#CC1(O)CN2CCC1CC2 |(13.38,-19.11,;12.04,-18.35,;10.71,-19.14,;9.37,-18.38,;10.73,-20.68,;12.08,-21.43,;12.09,-22.97,;10.76,-23.75,;10.77,-25.29,;9.43,-22.99,;9.41,-21.46,;8.1,-23.76,;6.78,-24.55,;5.45,-25.32,;5.43,-23.78,;5.45,-26.87,;4.11,-27.64,;2.77,-26.87,;2.77,-25.32,;4.11,-24.54,;3.37,-25.9,;4.86,-26.31,)| | ||
Structure |