Ki Summary

Reaction Details

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Target

Squalene synthase

Ligand

BDBM50270313

Substrate/Competitor

n/a

Meas. Tech.

ChEMBL_520603 (CHEMBL959525)

IC50

>1000±n/a nM

Citation

Cammerer, SB; Jimenez, C; Jones, S; Gros, L; Lorente, SO; Rodrigues, C; Rodrigues, JC; Caldera, A; Ruiz Perez, LM; da Souza, W; Kaiser, M; Brun, R; Urbina, JA; Gonzalez Pacanowska, D; Gilbert, IH Quinuclidine derivatives as potential antiparasitics. Antimicrob Agents Chemother51:4049-61 (2007) [PubMed] Article

More Info.:

Get all data from this article, Assay Method

Squalene synthase

Name:

Squalene synthase

Synonyms:

Farnesyltransferase, putative

Type:

PROTEIN

Mol. Mass.:

47117.40

Organism:

Leishmania major

Description:

ChEMBL_520603

Residue:

414

Sequence:

MGFFSDSVAMMRVKWQMRSVKIQVPPEETDLRFCYDIMNDVSRSFAVVVAQLADQQLRDA
ICIFYLVLRALDTLEDDMSVPVDVKLKELPKFHTHTSDMSWCMSGVGEGRERELLAKYPC
VSREFKKLKKEYQDVIANICERMANGMCEFLKRPVVTKDDYNQYCHYVAGLVGHGLTQLF
ARCGFEDPSLDDDLTSSNHMGLFLQKTNIIRDYYEDIREEPPRMFWPKEIWGTYVTELKE
LKSESNNAAAVQCLNAMVADALVHVPYIVDYLSALRDPSVFRFCAIPQVMAIATLKEVYN
NPDTFQVKVKVSRPESCRIMLKATTLYSSLSMFRDYCVELQEKLDMQDASSVSIANSLAA
AIERIDLQLKKCQDVSYTRSLLARYPGLGGQFLLTVMDTVAGFFGGRKEIAGHA

BDBM50270313

n/a

Name

BDBM50270313

Synonyms:

3-(2'-Naphtylmethyl)-quinuclidine | CHEMBL506873

Type

Small organic molecule

Emp. Form.

C18H21N

Mol. Mass.

251.366

SMILES

C(C1CN2CCC1CC2)c1ccc2ccccc2c1 |(-6.33,-28.4,;-7.67,-29.17,;-7.67,-30.71,;-9.01,-31.48,;-10.34,-30.71,;-10.34,-29.17,;-9.01,-28.39,;-9.74,-29.75,;-8.26,-30.15,;-5,-29.17,;-3.68,-28.4,;-2.35,-29.16,;-2.34,-30.71,;-1.01,-31.47,;-1.01,-33,;-2.35,-33.78,;-3.68,-33.01,;-3.68,-31.47,;-5.01,-30.71,)|

Structure